Pieta Mattila
InFLAMES Group Leader, Adjunct Professor
MediCity Research Laboratories, Turku Bioscience Centre pieta.mattila@utu.fi +358 29 450 4431 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0003-2805-0686 |
Immunology
B cells
Antigen receptor signaling
Cell biology
Actin cytoskeleton
Plasma membrane
Advanced microscopy
Education:
MSc in Biochemistry 2002 (University of Oulu, Finland)
PhD in Genetics 2008 (University of Helsinki)
Postdoc: Cancer Research UK, London Research Institute 2008-2012
Adjunct Professor: 2014
Group leader in the InFLAMES research flagship 2022-> (University of Turku)
Academy of Finland Research Fellow 2016-2022 (University of Turku)
B lymphocytes are key cells in mounting the adaptive immune response by differentiating into antibody secreting plasma cells. Our group is interested in the molecular mechanisms of B lymphocyte activation, with emphasis on receptor activation and its immediate cell biological responses, culminating at the reorganization of the actin cytoskeleton, plasma membrane and intracellular vesicle traffic. In our research, we take advantage of both in vivo models and various advanced imaging techniques, including super-resolution microscopy, as well as modern proteomic approaches such as APEX2 proximity biotinylation.
More information about our projects, including our publications, can be found at: http://mattilalab.utu.fi.
I am lecturing on various Master’s and PhD level courses on topics including the adaptive immune system, cell signaling, cytoskeleton, and microscopy. I have been involved in designing new courses targeted for PhD students and postdocs. I have done University Pedagogics 1 course to develop my pedagogic skills. At every day level, I am supervising
doctoral students, postdocs, as well as guide Master’s thesis projects.
- GlycoAvatars : bead-coated membrane models for studying the cancer-immune cells interactome (2026)
- Communications Biology
(A1 Refereed original research article in a scientific journal) - B cell mechanotransduction via ATAT1 coordinates actin and lysosomal dynamics at the immune synapse (2025)
- Journal of Cell Biology
(A1 Refereed original research article in a scientific journal) - Enhanced antibody responses in CD19-Cre mice (2025)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - High-Resolution Imaging of Intracellular Trafficking of B Cell Receptor Using Specific Hybridization Internalization Probe (SHIP) (2025) B-Cell Receptor Signaling - Methods and Protocols Hernández-Pérez, Sara; Mattila, Pieta K.
(A3 Refereed book chapter or chapter in a compilation book) - Dynamic Micropatterning Reveals Substrate-Dependent Differences in the Geometric Control of Cell Polarization and Migration (2024)
- Small Methods
(A1 Refereed original research article in a scientific journal) - Endolysosomal vesicles at the center of B cell activation (2024)
- Journal of Cell Biology
(A2 Refereed review article in a scientific journal ) - B cell receptor-induced protein dynamics and the emerging role of SUMOylation revealed by proximity proteomics (2023)
- Journal of Cell Science
(A1 Refereed original research article in a scientific journal) - CD73 regulates zoledronate-induced lymphocyte infiltration in triple-negative breast cancer tumors and lung metastases (2023)
- Frontiers in immunology
(A1 Refereed original research article in a scientific journal) - Isolation of the B Cell Immune Synapse for Proteomic Analysis (2023)
- Methods in Molecular Biology
(A3 Refereed book chapter or chapter in a compilation book) - The Small GTPase Rab7 Regulates Antigen Processing in B Cells in a Possible Interplay with Autophagy Machinery (2023)
- Cells
(A1 Refereed original research article in a scientific journal)



