PhD Pekka Rappu - UTU Research Portal

Pekka Rappu
PhD

- University Teacher,
Biochemistry (Department of Life Technologies)
- Docent,
Department of Life Technologies (Faculty of Technology)

pekrappu@utu.fi

+358 29 450 4785

Tykistökatu 6

Turku

: https://orcid.org/0000-0002-5068-2842

Research group: Structure and Function of Collagen Receptor Integrins

Extracellular matrix
Proteomics
Integrins

Solu ja biomolekyylit - käytäntö
Molekyylibiologia - käytäntö

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Integration of Matrisome Omics: Towards System Biology of the Tumor MatrisomeExtracellular citrullination inhibits the function of matrix associated TGF-beta (2020) Extracellular Matrix Omics Valerio Izzi, Jarkko Koivunen, Pekka Rappu, Jyrki Heino, Taina Pihlajaniemi
Interaction between prostate cancer cells and prostate fibroblasts promotes accumulation and proteolytic processing of basement membrane proteins (2020)
- ProstatePlatelets
Ojalill M, Virtanen N, Rappu P, Siljamäki E, Taimen P, Heino J
Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine (2020)
- Journal of Extracellular Vesicles
Dhondt B, Geeurickx E, Tulkens J, Van Deun J, Vergauwen G, Lippens L, Miinalainen I, Rappu P, Heino J, Ost P, Lumen N, De Wever O, Hendrix A
FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy (2019)
- eLife
Osterman CJD, Ozmadenci D, Kleinschmidt EG, Taylor KN, Barrie AM, Jiang SL, Bean LM, Sulzmaier FJ, Jean C, Tancioni I, Anderson K, Uryu S, Cordasco EA, Li J, Chen XL, Fu G, Ojalill M, Rappu P, Heino J, Mark AM, Xu GR, Fisch KM, Kolev VN, Weaver DT, Pachter JA, Gyorffy B, McHale MT, Connolly DC, Molinolo A, Stupack DG, Schlaepfer DD, Schlaepfer DD
Role of prolyl hydroxylation in the molecular interactions of collagens (2019)
- Essays in Biochemistry
Rappu P., Salo A., Myllyharju J., Heino J.
Integrin α2β1 decelerates proliferation, but promotes survival and invasion of prostate cancer cellsCharacterization of Intrinsically Disordered Prostate Associated Gene (PAGE5) at Single Residue Resolution by NMR Spectroscopy (2018)
- OncotargetPLoS ONE
Ojalill M., Parikainen M., Rappu P., Aalto E., Jokinen J., Virtanen N., Siljamäki E., Heino J.
Proline hydroxylation in collagen supports integrin binding by two distinct mechanisms (2018)
- Journal of Biological Chemistry
Kalle H. Sipilä, Kati Drushinin, Pekka Rappu, Johanna Jokinen, Tiina A. Salminen, Antti M. Salo, Jarmo Käpylä, Johanna Myllyharju, Jyrki Heino
The composition of prostate core matrisome in vivo and in vitro unveiled by mass spectrometric analysis (2018)
- Prostate
Marjaana Ojalill, Pekka Rappu, Elina Siljamäki, Pekka Taimen, Peter Boström, Jyrki Heino
Integrin α2β1 in nonactivated conformation can induce focal adhesion kinase signaling (2017)
- Scientific Reports
Salmela Maria, Jokinen Johanna, Tiitta Silja, Rappu Pekka, Cheng Holland R, Heino Jyrki
Joint inflammation related citrullination of functional arginines in extracellular proteins (2017)
- Scientific Reports
Sipila KH, Ranga V, Rappu P, Mali M, Pirila L, Heino I, Jokinen J, Kapyla J, Johnson MS, Heino J
(2016)
- Matrix Biology
Sipila KH, Ranga V, Rappu P, Torittu A, Pirila L, Kapyla J, Johnson MS, Larjava H, Heino J
Platelet response to a small molecule inhibitor of α2β1 integrin is associated with ITGA2 C807T dimorphism. (2016)
Nissinen L, Rappu P, Ollikka P, Nieminen J, Marjamäki A, Heino J
Tumor promoter PMA enhances kindlin-2 and decreases vimentin recruitment into cell adhesion sites (2016)
- International Journal of Biochemistry and Cell Biology
Salmela M, Rappu P, Lilja J, Niskanen H, Taipalus E, Jokinen J, Heino J
Melanoma-Associated Cancer-Testis Antigen 16 (CT16) Regulates the Expression of Apoptotic and Antiapoptotic Genes and Promotes Cell Survival (2012)
- PLoS ONE
Nylund C, Rappu P, Pakula E, Heino A, Laato L, Elo LL, Vihinen P, Pyrhonen S, Owen GR, Larjava H, Kallajoki M, Heino J
(2011)
Hellman M, Tossavainen H, Rappu P, Heino J, Permi P
Characterization of local structural features of intrinsically disordered cancer-testis antigen (CT16) at single residue resolution by NMR spectroscopy (2011)
- PLoS ONE
Maarit Hellman, Helena Tossavainen, Pekka Rappu, Jyrki Heino, Perttu Permi
Detection of melanoma-derived cancer-testis antigen CT16 in patient sera by a novel immunoassay (2011)
- International Journal of Cancer
Rappu P, Nylund C, Ristiniemi N, Kulpakko J, Vihinen P, Hernberg M, Mirtti T, Alanen K, Kallajoki M, Vuoristo MS, Pyrhonen S, Heino J
Detection of melanoma-derived cancer-testis antigen CT16 in patient sera by a novel immunoassay (2010)
- Journal of Investigative Dermatology
Rappu P, Nylund C, Ristiniemi N, Kulpakko J, Vihinen P, Hernberg M, Alanen K, Kallajoki M, Pyrhönen S, Heino J
Mutational analysis of the Bacillus subtilis purA operator site (2005)
- Current Microbiology
Rappu P, Leppihalme M, Mantsala P
In vivo effect of mutations at the PRPP binding site of the Bacillus subtilis purine repressor (2003)
- Journal of Bacteriology
Rappu P, Pullinen T, Mantsala P