PhD Pekka Rappu - UTU Research Portal

Pekka Rappu
PhD

- University Teacher,
Biochemistry (Department of Life Technologies)
- Docent,
Department of Life Technologies (Faculty of Technology)

pekrappu@utu.fi

+358 29 450 4785

Tykistökatu 6

Turku

ORCID identifier: https://orcid.org/0000-0002-5068-2842

Research group: Structure and Function of Collagen Receptor Integrins

Research

Extracellular matrix
Proteomics
Integrins

Teaching

Solu ja biomolekyylit - käytäntö
Molekyylibiologia - käytäntö

Publications

1 of 2

Expression of C1q by Macrophages and Fibroblasts in Tumor Microenvironment Is Associated with Progression and Metastasis of Cutaneous Squamous Cell Carcinoma (2025)
- Journal of Investigative Dermatology
Viiklepp, Kristina; Knuutila, Jaakko S.; Nissinen, Liisa; Siljamäki, Elina; Rappu, Pekka; Suwal, Ujjwal; Pellinen, Teijo; Kallajoki, Markku; Meri, Seppo; Heino, Jyrki; Kähäri, Veli-Matti; Riihilä, Pilvi
(A1 Refereed original research article in a scientific journal)
Sequential orthogonal assays for longitudinal and endpoint characterization of three-dimensional spheroids (2025)
- Nature Protocols
Blondeel, Eva; Ernst, Sam; De Vuyst, Felix; Diosdi, Akos; Pinheiro, Claudio; Estevao, Diogo; Rappu, Pekka; Boiy, Robin; Dedeyne, Sandor; Craciun, Ligia; Goossens, Vera; Dehairs, Jonas; Cruz, Tania; Audenaert, Dominique; Ceelen, Wim; Linnebacher, Michael; Boterberg, Tom; Vandesompele, Jo; Mestdagh, Pieter; Swinnen, Johan; Heino, Jyrki; Horvath, Peter; Oliveira, Maria Jose; Hendrix, An; De Metter, Pieter; De Wever, Olivier
(A1 Refereed original research article in a scientific journal)
Cancer-associated fibroblasts mediate resistance to neoadjuvant therapy in breast cancer (2024)
- Clinical and translational medicine
Xia, Zihan; Vermeulen, Stephanie; Suwal, Ujjwal; Rappu, Pekka; Heino, Jyrki; De Vuyst, Felix; Dedeyne, Sandor; Hendrix, An; Denys, Hannelore; De Wever, Olivier
(B1 Other refereed article (e.g., editorial, letter, comment) in a scientific journal)
Collagen prolyl 4-hydroxylase isoenzymes I and II have sequence specificity towards different X-Pro-Gly triplets (2024)
- Matrix Biology
Salo Antti M., Rappu Pekka, Koski M．Kristian, Karjalainen Emma, Izzi Valerio, Drushinin Kati, Miinalainen Ilkka, Käpylä Jarmo, Heino Jyrki, Myllyharju Johanna
(A1 Refereed original research article in a scientific journal)
Dual-ligand PROTACS mediate superior target protein degradation in vitro and therapeutic efficacy in vivo (2024)
- Chemical Science
Chen, Yong; Xia, Zihan; Suwal, Ujjwal; Rappu, Pekka; Heino, Jyrki; De Wever, Olivier; De Geest, Bruno G.
(A1 Refereed original research article in a scientific journal)
Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality in mice (2024)
- iScience
Talvi Salli, Jokinen Johanna, Sipilä Kalle, Rappu Pekka, Zhang Fu-Ping, Poutanen Matti, Rantakari Pia, Heino Jyrki
(A1 Refereed original research article in a scientific journal)
Pelophen B is a non-taxoid binding microtubule-stabilizing agent with promising preclinical anticancer properties (2024)
- Scientific Reports
Vermeulen, Stephanie; Ernst, Sam; Blondeel, Eva; Xia, Zihan; Rappu, Pekka; Heino, Jyrki; Dedeyne, Sándor; Denys, Hannelore; Sys, Gwen; Gijsels, Stefanie; Depypere, Herman; Tummers, Philippe; Ceelen, Wim; Craciun, Ligia; Demetter, Pieter; Raes, Olivier; Hendrix, An; Van der Eycken, Johan; De Wever, Olivier
(A1 Refereed original research article in a scientific journal)
Benchmarking blood collection tubes and processing intervals for extracellular vesicle performance metrics (2023)
- Journal of Extracellular Vesicles
Dhondt Bert, Pinheiro Cláudio, Geeurickx Edward, Tulkens Joeri, Vergauwen Glenn, Van Der Pol Edwin, Nieuwland Rienk, Decock Anneleen, Miinalainen Ilkka, Rappu Pekka, Schroth Gary, Kuersten Scott, Vandesompele Jo, Mestdagh Pieter, Lumen Nicolaas, De Wever Olivier, Hendrix An
(A1 Refereed original research article in a scientific journal)
Inhibition of TGF-β signaling, invasion, and growth of cutaneous squamous cell carcinoma by PLX8394 (2023)
- Oncogene
Siljamäki Elina, Riihilä Pilvi, Suwal Ujjwal, Nissinen Liisa, Rappu Pekka, Kallajoki Markku, Kähäri Veli-Matti, Heino Jyrki
(A1 Refereed original research article in a scientific journal)
Integrating automated liquid handling in the separation workflow of extracellular vesicles enhances specificity and reproducibility (2023)
- Journal of Nanobiotechnology
Van Dorpe Sofie, Lippens Lien, Boiy Robin, Pinheiro Cláudio, Vergauwen Glenn, Rappu Pekka, Miinalainen Ilkka, Tummers Philippe, Denys Hannelore, De Wever Olivier, Hendrix An
(A1 Refereed original research article in a scientific journal)
Inflammation-related citrullination of matrisome proteins in human cancer (2022)
- Frontiers in Oncology
Rappu Pekka, Suwal Ujjwal, Siljamäki Elina, Heino Jyrki
(A1 Refereed original research article in a scientific journal)
Recombinant extracellular vesicles as biological reference material for method development, data normalization and assessment of (pre-)analytical variables (2021)
- Nature Protocols
Geeurickx Edward, Lippens Lien, Rappu Pekka, De Geest Bruno G, De Wever Olivier, Hendrix An
(A1 Refereed original research article in a scientific journal)
Feasibility of Mechanical Extrusion to Coat Nanoparticles with Extracellular Vesicle Membranes (2020)
- Cells
Van Deun J, Roux Q, Deville S, Van Acker T, Rappu P, Miinalainen I, Heino J, Vanhaecke F, De Geest BG, De Wever O, Hendrix A
(A1 Refereed original research article in a scientific journal)
H-Ras activation and fibroblast-induced TGF-β signaling promote laminin-332 accumulation and invasion in cutaneous squamous cell carcinoma (2020)
- Matrix Biology
Siljamäki E, Rappu P, Riihilä P, Nissinen L, Kähäri VM, Heino J.
(A1 Refereed original research article in a scientific journal)
Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction (2020)
- Gut
Tulkens Joeri, Vergauwen Glenn, Van Deun Jan, Geeurickx Edward, Dhondt Bert, Lippens Lien, De Scheerder Marie-Angelique, Miinalainen Ilkka, Rappu Pekka, De Geest Bruno G, Vandecasteele Katrien, Laukens Debby, Vandekerckhove Linos, Denys Hannelore, Vandesompele Jo, De Wever Olivier, Hendrix An
(A1 Refereed original research article in a scientific journal)
Integration of Matrisome Omics: Towards System Biology of the Tumor Matrisome (2020) Extracellular Matrix Omics Valerio Izzi, Jarkko Koivunen, Pekka Rappu, Jyrki Heino, Taina Pihlajaniemi
(A3 Refereed book chapter or chapter in a compilation book)
Interaction between prostate cancer cells and prostate fibroblasts promotes accumulation and proteolytic processing of basement membrane proteins (2020)
- Prostate
Ojalill M, Virtanen N, Rappu P, Siljamäki E, Taimen P, Heino J
(A1 Refereed original research article in a scientific journal)
Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine (2020)
- Journal of Extracellular Vesicles
Dhondt B, Geeurickx E, Tulkens J, Van Deun J, Vergauwen G, Lippens L, Miinalainen I, Rappu P, Heino J, Ost P, Lumen N, De Wever O, Hendrix A
(A1 Refereed original research article in a scientific journal)
FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy (2019)
- eLife
Osterman CJD, Ozmadenci D, Kleinschmidt EG, Taylor KN, Barrie AM, Jiang SL, Bean LM, Sulzmaier FJ, Jean C, Tancioni I, Anderson K, Uryu S, Cordasco EA, Li J, Chen XL, Fu G, Ojalill M, Rappu P, Heino J, Mark AM, Xu GR, Fisch KM, Kolev VN, Weaver DT, Pachter JA, Gyorffy B, McHale MT, Connolly DC, Molinolo A, Stupack DG, Schlaepfer DD, Schlaepfer DD
(A1 Refereed original research article in a scientific journal)
Role of prolyl hydroxylation in the molecular interactions of collagens (2019)
- Essays in Biochemistry
Rappu P., Salo A., Myllyharju J., Heino J.
(A2 Refereed review article in a scientific journal )