Ilkka Paatero
Ph.D.
ilanpa@utu.fi +358 29 450 3789 Tykistökatu 6 Turku |
cancer; cardiovascular biology; toxicology; microscopy; zebrafish models; model organisms;
My research covers broad range of topics in biomedicine. Current work is dealing mainly with cancer and cardiovascular biology.
My expertise is in application of model organisms, especially zebrafish (Danio rerio),
in biomedical research. These models can help to understand and solve
biomedical problems efficiently and ethically. Especially, when combined
with high-resolution intravital microscopy, these models can give deep
insights into developmental and disease processes in vivo. By using fish
eggs and embryos, it is also possible to reduce the number of more
complex and developed organisms used in research. These models, however, require certain set of skills and knowledge which is not part of the training of most medical and biomedical scientist. To facilite them to utilize the power of zebrafish models to advance their research, I have established a Zebrafish Core under Turku Centre for Biotechnology (University of Turku and Åbo Akademi University).
- SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling (2021)
- Current Biology
- Stromal interaction molecule 1 (STIM1) knock down attenuates invasion and proliferation and enhances the expression of thyroid-specific proteins in human follicular thyroid cancer cells (2021)
- Cellular and Molecular Life Sciences
- Genetic and functional implications of an exonic TRIM55 variant in heart failure (2020)
- Journal of Molecular and Cellular Cardiology
- An unbiased in vitro screen for activating epidermal growth factor receptor mutations (2019)
- Journal of Biological Chemistry
- Combined inhibition of tumor suppressors PTEN and PP2A drives anoikis resistance and is associated with therapy relapse in prostate cancer (2019)
- Cancer Research
- ErbB4 tyrosine kinase inhibition impairs neuromuscular development in zebrafish embryos (2019)
- Molecular Biology of the Cell
- GGA2 and RAB13 promote activity-dependent β1-integrin recycling (2019)
- Journal of Cell Science
- Helppokäyttöinen seeprakala tutkijan apuna (2019)
- Solubiologi
- SORLA regulates endosomal trafficking and oncogenic fitness of HER2 (2019)
- Nature Communications
- Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction (2018)
- Nature Communications
- Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and beta 1-integrin activation (2018)
- eLife
- Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target (2018)
- BMC Cardiovascular Disorders
- Zebrafish Embryo Xenograft and Metastasis Assay (2018)
- Bio-protocol
- Analyses in zebrafish embryos reveal that nanotoxicity profiles are dependent on surface- functionalization controlled penetrance of biological membranes (2017)
- Scientific Reports
- FiloQuant reveals increased filopodia density during breast cancer progression (2017)
- Journal of Cell Biology
- Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts (2015)
- PLoS ONE
- Plasminogen Activator Inhibitor-1 Controls Vascular Integrity by Regulating VE-Cadherin Trafficking (2015)
- PLoS ONE
- Hypoxia-inducible Factor-1α Induces ErbB4 Signaling in the Differentiating Mammary Gland (2014)
- Journal of Biological Chemistry
- CYT-1 isoform of ErbB4 is an independent prognostic factor in serous ovarian cancer and selectively promotes ovarian cancer cell growth in vitro (2013)
- Gynecologic Oncology
- Novel functions of ErbB4 and NRG-1 in development and cancer (2013) Paatero Ilkka