Ilkka Paatero
Ph.D.
ilanpa@utu.fi +358 29 450 3789 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0001-5926-2396 |
cancer; cardiovascular biology; toxicology; microscopy; zebrafish models; model organisms;
My research covers broad range of topics in biomedicine. Current work is dealing mainly with cancer and cardiovascular biology.
My expertise is in application of model organisms, especially zebrafish (Danio rerio),
in biomedical research. These models can help to understand and solve
biomedical problems efficiently and ethically. Especially, when combined
with high-resolution intravital microscopy, these models can give deep
insights into developmental and disease processes in vivo. By using fish
eggs and embryos, it is also possible to reduce the number of more
complex and developed organisms used in research. These models, however, require certain set of skills and knowledge which is not part of the training of most medical and biomedical scientist. To facilite them to utilize the power of zebrafish models to advance their research, I have established a Zebrafish Core under Turku Centre for Biotechnology (University of Turku and Åbo Akademi University).
- High-resolution live imaging of tardigrade response to anoxia (2025)
- Micron
(A1 Refereed original research article in a scientific journal) - DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer (2024)
- EMBO Molecular Medicine
(A1 Refereed original research article in a scientific journal) - Empagliflozin attenuates hypoxia-induced heart failure of zebrafish embryos via influencing MMP13 expression (2024)
- Biomedicine and Pharmacotherapy
(A1 Refereed original research article in a scientific journal) - Glutaraldehyde-enhanced autofluorescence as a general tool for 3D morphological imaging (2024)
- Biology Open
(A1 Refereed original research article in a scientific journal) - Heat stress sensitizes zebrafish embryos to neurological and cardiac toxicity (2024)
- Biochemical and Biophysical Research Communications
(A1 Refereed original research article in a scientific journal) - HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis (2024)
- Journal of Experimental and Clinical Cancer Research
(A1 Refereed original research article in a scientific journal) - Jnk1 and downstream signalling hubs regulate anxiety-like behaviours in a zebrafish larvae phenotypic screen (2024)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - SIX2 promotes cell plasticity via Wnt/β-catenin signalling in androgen receptor independent prostate cancer (2024)
- Nucleic Acids Research
(A1 Refereed original research article in a scientific journal) - TLNRD1 is a CCM complex component and regulates endothelial barrier integrity (2024)
- Journal of Cell Biology
(A1 Refereed original research article in a scientific journal) - Effect of caldesmon mutations in the development of zebrafish embryos (2023)
- Biochemical and Biophysical Research Communications
(A1 Refereed original research article in a scientific journal) - Glucocorticoid receptor-induced non-muscle caldesmon regulates metastasis in castration-resistant prostate cancer (2023)
- Oncogenesis
(A1 Refereed original research article in a scientific journal) - Impaired fin regeneration and angiogenesis in aged zebrafish and turquoise killifish (2023)
- Biology Open
(A1 Refereed original research article in a scientific journal) - Modeling of Zebrafish Housing Temperatures During Power Outage and Instrument Failure (2023)
- Zebrafish
(A1 Refereed original research article in a scientific journal) - PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers (2023)
- Molecular Oncology
(A1 Refereed original research article in a scientific journal) - STAT5b is a key effector of NRG-1/ERBB4-mediated myocardial growth (2023)
- EMBO Reports
(A1 Refereed original research article in a scientific journal) - Distinctive effects of SGLT2 inhibitors on angiogenesis in zebrafish embryos (2022)
- Biomedicine and Pharmacotherapy
(A1 Refereed original research article in a scientific journal) - MYO10-filopodia support basement membranes at pre-invasive tumor boundaries (2022)
- Developmental Cell
(A1 Refereed original research article in a scientific journal) - A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance (2021)
- Oncogene
(A1 Refereed original research article in a scientific journal) - Combined genetic and chemical screens indicate protective potential for EGFR inhibition to cardiomyocytes under hypoxia (2021)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Control of dynamic cell behaviors during angiogenesis and anastomosis by Rasip1 (2021)
- Development
(A1 Refereed original research article in a scientific journal)