Ilkka Paatero
Ph.D.
ilanpa@utu.fi +358 29 450 3789 Tykistökatu 6 Turku |
cancer; cardiovascular biology; toxicology; microscopy; zebrafish models; model organisms;
My research covers broad range of topics in biomedicine. Current work is dealing mainly with cancer and cardiovascular biology.
My expertise is in application of model organisms, especially zebrafish (Danio rerio),
in biomedical research. These models can help to understand and solve
biomedical problems efficiently and ethically. Especially, when combined
with high-resolution intravital microscopy, these models can give deep
insights into developmental and disease processes in vivo. By using fish
eggs and embryos, it is also possible to reduce the number of more
complex and developed organisms used in research. These models, however, require certain set of skills and knowledge which is not part of the training of most medical and biomedical scientist. To facilite them to utilize the power of zebrafish models to advance their research, I have established a Zebrafish Core under Turku Centre for Biotechnology (University of Turku and Åbo Akademi University).
- High-resolution live imaging of tardigrade response to anoxia (2025)
- Micron
- DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer (2024)
- EMBO Molecular Medicine
- Empagliflozin attenuates hypoxia-induced heart failure of zebrafish embryos via influencing MMP13 expression (2024)
- Biomedicine and Pharmacotherapy
- Glutaraldehyde-enhanced autofluorescence as a general tool for 3D morphological imaging (2024)
- Biology Open
- Heat stress sensitizes zebrafish embryos to neurological and cardiac toxicity (2024)
- Biochemical and Biophysical Research Communications
- HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis (2024)
- Journal of Experimental and Clinical Cancer Research
- Jnk1 and downstream signalling hubs regulate anxiety-like behaviours in a zebrafish larvae phenotypic screen (2024)
- Scientific Reports
- SIX2 promotes cell plasticity via Wnt/β-catenin signalling in androgen receptor independent prostate cancer (2024)
- Nucleic Acids Research
- TLNRD1 is a CCM complex component and regulates endothelial barrier integrity (2024)
- Journal of Cell Biology
- Effect of caldesmon mutations in the development of zebrafish embryos (2023)
- Biochemical and Biophysical Research Communications
- Glucocorticoid receptor-induced non-muscle caldesmon regulates metastasis in castration-resistant prostate cancer (2023)
- Oncogenesis
- Impaired fin regeneration and angiogenesis in aged zebrafish and turquoise killifish (2023)
- Biology Open
- Modeling of Zebrafish Housing Temperatures During Power Outage and Instrument Failure (2023)
- Zebrafish
- PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers (2023)
- Molecular Oncology
- STAT5b is a key effector of NRG-1/ERBB4-mediated myocardial growth (2023)
- EMBO Reports
- Distinctive effects of SGLT2 inhibitors on angiogenesis in zebrafish embryos (2022)
- Biomedicine and Pharmacotherapy
- MYO10-filopodia support basement membranes at pre-invasive tumor boundaries (2022)
- Developmental Cell
- A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance (2021)
- Oncogene
- Combined genetic and chemical screens indicate protective potential for EGFR inhibition to cardiomyocytes under hypoxia (2021)
- Scientific Reports
- Control of dynamic cell behaviors during angiogenesis and anastomosis by Rasip1 (2021)
- Development