Hannu Järveläinen
Professor
hanjar@utu.fi +358 29 450 4629 +358 46 922 9617 Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/https://orcid.org/0000-0002-1061-6779 |
extracellular matrix; proteoglycans; decorin; hyaluronan, vascular biology, cancer biology, diabetes, biobank
The extracellular matrix (ECM) consists of numerous macromolecules that
can be classified into collagens, elastin, and microfibrillar proteins,
proteoglycans including hyaluronan, and noncollagenous glycoproteins.
Together they form a complex, three-dimensional network among the cells
of different tissues in an organ-specific manner. In addition to being
necessary structural components, ECM macromolecules exhibit important
functional roles in the control of key cellular events such as adhesion,
migration, proliferation, differentiation, and survival. Any structural
inherited or acquired defect and/or metabolic disturbance in the ECM
macromolecules may cause cellular and tissue alterations that can lead
to the development or progression of disease. Consequently, ECM
macromolecules are important targets for pharmacotherapy. Our interest
has been for a long time to study the role of matrix proteoglycans (PGs)
including hyaluronan in vascular biology. We have particularly focused
on the involvement of a small PG decorin with atherogenesis and
angiogenesis. Lately we have also examined the role of decorin in
tumourigenesis. Our ultimate goal is to develop decorin-based therapies
to prevent luminal narrowing of arteries, to inhibit pathological
angiogenesis and to restrict tumour growth and metastasis.
- Attenuated Replication-Competent Herpes Simplex Virus Expressing an ECM-Modifying Transgene Hyaluronan Synthase 2 of Naked Mole Rat in Oncolytic Gene Therapy (2023)
- Microorganisms
(Refereed journal article or data article (A1)) - Common variable immunodeficiency-an independent risk factor for atherosclerotic cardiovascular diseases (2023)
- Frontiers in Cardiovascular Medicine
(Refereed journal article or data article (A1)) - Diabeettinen neuropatia alaraajoissa (2023) Jalkaterveys Järveläinen Hannu, Lahtela Jorma, Ebeling Tapani
(Article in a professional research book (D2)) - Diabetesta sairastavan jalkaterien verisuonien perustutkimus (2023) Jalkaterveys Järveläinen Hannu, Ebeling Tapani
(Article in a professional research book (D2)) - Hypertension in NF1: A closer look at the primacy of essential hypertension versus secondary causes (2023)
- Molecular Genetics and Genomic Medicine
(Refereed journal article or data article (A1)) - Iäkkään naisen tajunnan heikkeneminen, laaja-alainen turvotus ja hengitysvaikeus : vinkistä vihiä + vastaus (2023)
- Duodecim
(Article in trade journal or blog post (D1)) - Ohje 28.62 Diabetesta sairastavan jalkavaurioiden jälkihoito (2023) Jalkaterveys Järveläinen Hannu, Lahtela Jorma, Ebeling Tapani
(Article in a professional research book (D2)) - Distinctive effects of SGLT2 inhibitors on angiogenesis in zebrafish embryos (2022)
- Biomedicine and Pharmacotherapy
(Refereed journal article or data article (A1)) - Lihasinfarkti: harvinainen diabeteksen komplikaatio keski-ikäisellä naisella (2022)
- Lääkärilehti
(Refereed journal article or data article (A1)) - Systeeminen kevytketjuamyloidoosi - diagnostinen haaste (2022)
- Duodecim
(Article in trade journal or blog post (D1)) - Tyypin 2 diabeteksen ja esidiabeteksen hoito Varsinais-Suomessa - ollaanko tavoitteissa? (2022)
- Yleislääkäri
(Refereed journal article or data article (A1)) - Ehlers-Danlosin oireyhtymä ja päänahan kalkkikertymät nuorella naisella (2021)
- Duodecim
(Article in trade journal or blog post (D1)) - Esidiabetes lisää valtimotautien riskiä – entä hoidon kustannuksia? (2021)
- Lääkärilehti
Rautava Päivi
(Refereed journal article or data article (A1)) - Haploinsufficiency of the NF1 gene is associated with protection against diabetes (2021)
- Journal of Medical Genetics
(Refereed journal article or data article (A1)) - Diabeetikon ajoterveys (2020)
- Erikoislääkäri
(Article in trade journal or blog post (D1)) - Diabeteksen hoidon toteutuminen ja kustannukset perusterveydenhuollossa: Esimerkkinä Paimion–Sauvon kansanterveyskuntayhtymä (2020)
- Lääkärilehti
(Refereed journal article or data article (A1)) - Extracellular matrix-cell interactions: Focus on therapeutic applications (2020)
- Cellular Signalling
(Refereed journal article or data article (A1)) - Haavan paraneminen - diabetes sekä muut esteet ja hidasteet (2020)
- Duodecim
(Refereed review article in scientific journal (A2)) - Metformin decreases hyaluronan synthesis by vascular smooth muscle cells (2020)
- Journal of Investigative Medicine
(Refereed journal article or data article (A1)) - Ajaessa ilmenevä hypoglykemia (2019) Diabetes Hannu Järveläinen
(Article in a professional research book (D2))