A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Influence de la mécanique des fluides sur la formation des métastases
(Influence of fluid mechanics on metastasis formation)
Tekijät: Follain Gautier, Gensbittel Valentin, Mary Benjamin, Lefebvre Olivier, Harlepp Sébastien, Hyenne Vincent, Goetz Jacky G.
Kustantaja: SRMS
Julkaisuvuosi: 2020
Journal: médecine/sciences
Tietokannassa oleva lehden nimi: M S-MEDECINE SCIENCES
Lehden akronyymi: M S-MED SCI
Vuosikerta: 36
Numero: 10
Aloitussivu: 872
Lopetussivu: 878
Sivujen määrä: 7
ISSN: 0767-0974
DOI: https://doi.org/10.1051/medsci/2020158
Verkko-osoite: https://www.medecinesciences.org/en/articles/medsci/full_html/2020/08/msc200114/msc200114.html
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/69176112
Metastases are the main cause of cancer-related deaths. The chain of events leading to their development is called "the metastatic cascade". The biological and biochemical aspects of this process have been well studied but the importance of biomechanical parameters only recently became a focus in the field. Studies have shown the biological fluids (blood, lymph and interstitial fluid) to play a key role in the metastatic cascade. These fluids participate in the transport of circulating tumor cells (CTCs) as well as the factors that they secrete, while at the same time influencing the events of the metastatic cascade through the forces that they generate. The hemodynamic properties and topological constraints of the vascular architecture control the formation of metastatic niches and the metastatic potential of tumor cells. In this review, we discuss the importance of these mechanical forces and highlight the novel questions and research avenues that they open.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
