A2 Refereed review article in a scientific journal
Influence de la mécanique des fluides sur la formation des métastases
(Influence of fluid mechanics on metastasis formation)
Authors: Follain Gautier, Gensbittel Valentin, Mary Benjamin, Lefebvre Olivier, Harlepp Sébastien, Hyenne Vincent, Goetz Jacky G.
Publisher: SRMS
Publication year: 2020
Journal: médecine/sciences
Journal name in source: M S-MEDECINE SCIENCES
Journal acronym: M S-MED SCI
Volume: 36
Issue: 10
First page : 872
Last page: 878
Number of pages: 7
ISSN: 0767-0974
DOI: https://doi.org/10.1051/medsci/2020158
Web address : https://www.medecinesciences.org/en/articles/medsci/full_html/2020/08/msc200114/msc200114.html
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/69176112
Metastases are the main cause of cancer-related deaths. The chain of events leading to their development is called "the metastatic cascade". The biological and biochemical aspects of this process have been well studied but the importance of biomechanical parameters only recently became a focus in the field. Studies have shown the biological fluids (blood, lymph and interstitial fluid) to play a key role in the metastatic cascade. These fluids participate in the transport of circulating tumor cells (CTCs) as well as the factors that they secrete, while at the same time influencing the events of the metastatic cascade through the forces that they generate. The hemodynamic properties and topological constraints of the vascular architecture control the formation of metastatic niches and the metastatic potential of tumor cells. In this review, we discuss the importance of these mechanical forces and highlight the novel questions and research avenues that they open.
Downloadable publication This is an electronic reprint of the original article. |  |
