High dose of red wine elicits enhanced inhibition of fibrinolysis



: Kiviniemi TO, Saraste A, Lehtimaki T, Toikka JO, Saraste M, Raitakari IT, Parkka JP, Hartiala JJ, Viikari J, Koskenvuo JW

Publisher: SAGE PUBLICATIONS LTD

: 2009

: European Journal of Cardiovascular Prevention and Rehabilitation

: EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION

: EUR J CARDIOV PREV R

: 16

: 161

: 163

: 3

: 1741-8267

DOI: https://doi.org/10.1097/HJR.0b013e328320ad1b

: https://academic.oup.com/eurjpc/article/16/2/161/5931818


Background and design The purpose of this randomized controlled cross-over study was to determine the acute effects of high doses of alcoholic beverages on circulating markers related to atherosclerosis and fibrinolysis.Methods Twenty-two healthy men consumed a high dose (8.1 +/- 0.9 dl) of alcohol-containing red wine and dealcoholized red wine, and an equal ethanol dose of cognac (2.4 +/- 0.3 dl). Blood samples were taken before and shortly after interventions.Results Red wine, unlike dealcoholized red wine and cognac, increased tissue plasminogen activator inhibitor-1 levels significantly, indicating an acute inhibition of fibrinolysis after a high dose.Conclusion Findings may explain the increased risk of cardiovascular mortality among binge drinkers. Eur J Cardiovasc Prev Rehabil 16:161-163 (C) 2009 The European Society of Cardiology



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