A1 Refereed original research article in a scientific journal

High dose of red wine elicits enhanced inhibition of fibrinolysis




AuthorsKiviniemi TO, Saraste A, Lehtimaki T, Toikka JO, Saraste M, Raitakari IT, Parkka JP, Hartiala JJ, Viikari J, Koskenvuo JW

PublisherSAGE PUBLICATIONS LTD

Publication year2009

JournalEuropean Journal of Cardiovascular Prevention and Rehabilitation

Journal name in sourceEUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION

Journal acronymEUR J CARDIOV PREV R

Volume16

First page 161

Last page163

Number of pages3

ISSN1741-8267

DOIhttps://doi.org/10.1097/HJR.0b013e328320ad1b

Web address https://academic.oup.com/eurjpc/article/16/2/161/5931818


Abstract
Background and design The purpose of this randomized controlled cross-over study was to determine the acute effects of high doses of alcoholic beverages on circulating markers related to atherosclerosis and fibrinolysis.Methods Twenty-two healthy men consumed a high dose (8.1 +/- 0.9 dl) of alcohol-containing red wine and dealcoholized red wine, and an equal ethanol dose of cognac (2.4 +/- 0.3 dl). Blood samples were taken before and shortly after interventions.Results Red wine, unlike dealcoholized red wine and cognac, increased tissue plasminogen activator inhibitor-1 levels significantly, indicating an acute inhibition of fibrinolysis after a high dose.Conclusion Findings may explain the increased risk of cardiovascular mortality among binge drinkers. Eur J Cardiovasc Prev Rehabil 16:161-163 (C) 2009 The European Society of Cardiology



Last updated on 2024-26-11 at 16:17