Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection

: Aguilera-Correa John Jairo, Fernández-López Sara, Cuñas-Figueroa Iskra Denise, Pérez-Rial Sandra, Alakomi Hanna-Leena, Nohynek Liisa, Oksman-Caldentey Kirsi-Marja, Salminen Juha-Pekka, Esteban Jaime, Cuadros Juan, Puupponen-Pimiä Riitta, Perez-Tanoira Ramon, Kinnari Teemu J.

Publisher: MDPI

: Basel

: 2021

: Antibiotics

: ANTIBIOTICS-BASEL

: ARTN 1481

: 10

: 12

: 15

: 2079-6382

DOI: https://doi.org/10.3390/antibiotics10121481

: https://doi.org/10.3390/antibiotics10121481

: https://research.utu.fi/converis/portal/detail/Publication/68733411

Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins such as sanguiin H-6 and lambertianin C, the main phenolic compounds in Rubus seeds, have shown antimicrobial activity. The aim of this study was to evaluate the effect of sanguiin H-6 and lambertianin C fractionated from cloudberry seeds, on the MRSA growth, and as treatment of a MRSA biofilm development in different growth media in vitro and in vivo by using a murine wound infection model where sanguiin H-6 and lambertianin C were used to prevent the MRSA infection. Sanguiin H-6 and lambertianin C inhibited the in vitro biofilm development and growth of MRSA. Furthermore, sanguiin H-6 showed significant anti-MRSA effect in the in vivo wound model. Our study shows the possible use of sanguiin H-6 as a preventive measure in surgical sites to avoid postoperative infections, whilst lambertianin C showed no anti-MRSA activity.

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