A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection
Tekijät: Aguilera-Correa John Jairo, Fernández-López Sara, Cuñas-Figueroa Iskra Denise, Pérez-Rial Sandra, Alakomi Hanna-Leena, Nohynek Liisa, Oksman-Caldentey Kirsi-Marja, Salminen Juha-Pekka, Esteban Jaime, Cuadros Juan, Puupponen-Pimiä Riitta, Perez-Tanoira Ramon, Kinnari Teemu J.
Kustantaja: MDPI
Kustannuspaikka: Basel
Julkaisuvuosi: 2021
Journal: Antibiotics
Tietokannassa oleva lehden nimi: ANTIBIOTICS-BASEL
Lehden akronyymi: ANTIBIOTICS-BASEL
Artikkelin numero: ARTN 1481
Vuosikerta: 10
Numero: 12
Sivujen määrä: 15
ISSN: 2079-6382
eISSN: 2079-6382
DOI: https://doi.org/10.3390/antibiotics10121481
Verkko-osoite: https://doi.org/10.3390/antibiotics10121481
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/68733411
Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins such as sanguiin H-6 and lambertianin C, the main phenolic compounds in Rubus seeds, have shown antimicrobial activity. The aim of this study was to evaluate the effect of sanguiin H-6 and lambertianin C fractionated from cloudberry seeds, on the MRSA growth, and as treatment of a MRSA biofilm development in different growth media in vitro and in vivo by using a murine wound infection model where sanguiin H-6 and lambertianin C were used to prevent the MRSA infection. Sanguiin H-6 and lambertianin C inhibited the in vitro biofilm development and growth of MRSA. Furthermore, sanguiin H-6 showed significant anti-MRSA effect in the in vivo wound model. Our study shows the possible use of sanguiin H-6 as a preventive measure in surgical sites to avoid postoperative infections, whilst lambertianin C showed no anti-MRSA activity.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
