A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Dysphagia, hypothyroidism, and osteoradionecrosis after radiation therapy for head and neck cancer
Tekijät: Ranta Pihla, Kytö Eero, Nissi Linda, Kinnunen Ilpo, Vahlberg Tero, Minn Heikki, Haapio Eeva, Nelimarkka Lassi, Irjala Heikki
Kustantaja: Wiley
Julkaisuvuosi: 2022
Journal: Laryngoscope Investigative Otolaryngology
Lehden akronyymi: LIO
Vuosikerta: 7
Numero: 1
Aloitussivu: 108
Lopetussivu: 116
DOI: https://doi.org/10.1002/lio2.711
Verkko-osoite: https://doi.org/10.1002/lio2.711
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/68078518
Objectives
To analyze the long-term side effects of radiation therapy (RT) for head and neck cancer (HNC).
MethodsRetrospective chart analysis of all 688 HNC patients treated during 2010–2015 at Turku University Hospital, Finland. All patients who survived for more than a year after RT/chemoRT were included (n = 233). Intensity modulated RT (IMRT) with standard fractionation was applied in each case.
ResultsOne hundred and six patients (45%) reported persisting dysphagia, for which neck RT increased risk. Definitive neck RT to high-risk volume did not increase late toxicity risks compared to elective neck RT. Radiation-induced hypothyroidism (29%, n = 67) was more common among younger patients and females. Osteoradionecrosis (12%, n = 29) was more common in the oral cavity cancer group (20.7%, n = 92) compared to all other subsites.
ConclusionsLate toxicities of RT for HNC are common. Age, gender, tumor subsite, and neck RT affect susceptibility to long-term side effects.
Level of evidence4.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
