A1 Refereed original research article in a scientific journal

Dysphagia, hypothyroidism, and osteoradionecrosis after radiation therapy for head and neck cancer



Authors: Ranta Pihla, Kytö Eero, Nissi Linda, Kinnunen Ilpo, Vahlberg Tero, Minn Heikki, Haapio Eeva, Nelimarkka Lassi, Irjala Heikki

Publisher: Wiley

Publication year: 2022

Journal: Laryngoscope Investigative Otolaryngology

Journal acronym: LIO

Volume: 7

Issue: 1

First page : 108

Last page: 116

DOI: https://doi.org/10.1002/lio2.711

Web address : https://doi.org/10.1002/lio2.711

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/68078518


Abstract
Objectives

To analyze the long-term side effects of radiation therapy (RT) for head and neck cancer (HNC).

Methods

Retrospective chart analysis of all 688 HNC patients treated during 2010–2015 at Turku University Hospital, Finland. All patients who survived for more than a year after RT/chemoRT were included (n = 233). Intensity modulated RT (IMRT) with standard fractionation was applied in each case.

Results

One hundred and six patients (45%) reported persisting dysphagia, for which neck RT increased risk. Definitive neck RT to high-risk volume did not increase late toxicity risks compared to elective neck RT. Radiation-induced hypothyroidism (29%, n = 67) was more common among younger patients and females. Osteoradionecrosis (12%, n = 29) was more common in the oral cavity cancer group (20.7%, n = 92) compared to all other subsites.

Conclusions

Late toxicities of RT for HNC are common. Age, gender, tumor subsite, and neck RT affect susceptibility to long-term side effects.

Level of evidence

4.


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Last updated on 2024-26-11 at 22:33