A2 Refereed review article in a scientific journal
Imaging in focus: An introduction to denoising bioimages in the era of deep learning
Authors: Laine Romain F., Jacquemet Guillaume, Krull Alexander
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publication year: 2021
Journal: International Journal of Biochemistry and Cell Biology
Journal name in source: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Journal acronym: INT J BIOCHEM CELL B
Article number: 106077
Volume: 140
Number of pages: 9
ISSN: 1357-2725
eISSN: 1878-5875
DOI: https://doi.org/10.1016/j.biocel.2021.106077(external)
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/67531966(external)
Fluorescence microscopy enables the direct observation of previously hidden dynamic processes of life, allowing profound insights into mechanisms of health and disease. However, imaging of live samples is fundamentally limited by the toxicity of the illuminating light and images are often acquired using low light conditions. As a consequence, images can become very noisy which severely complicates their interpretation. In recent years, deep learning (DL) has emerged as a very successful approach to remove this noise while retaining the useful signal. Unlike classical algorithms which use well-defined mathematical functions to remove noise, DL methods learn to denoise from example data, providing a powerful content-aware approach. In this review, we first describe the different types of noise that typically corrupt fluorescence microscopy images and introduce the denoising task. We then present the main DL-based denoising methods and their relative advantages and disadvantages. We aim to provide insights into how DL-based denoising methods operate and help users choose the most appropriate tools for their applications.
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