B1 Non-refereed article in a scientific journal
Small airway function in Finnish COVID-19 survivors
Authors: Lindahl Anna, Reijula Jere, Malmberg Leo Pekka, Aro Miia, Vasankari Tuula, Mäkelä Mika Juhani
Publisher: BMC
Publication year: 2021
Journal: Respiratory Research
Journal name in source: RESPIRATORY RESEARCH
Journal acronym: RESP RES
Article number: ARTN 237
Volume: 22
Issue: 1
Number of pages: 5
eISSN: 1465-993X
DOI: https://doi.org/10.1186/s12931-021-01830-9
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/67273571
Abstract
Follow-up studies of COVID-19 patients have found lung function impairment up to six months after initial infection, but small airway function has not previously been studied. Patients (n = 20) hospitalised for a severe SARS-CoV-2 infection underwent spirometry, impulse oscillometry, and multiple measurements of alveolar nitric oxide three to six months after acute infection. None of the patients had small airway obstruction, nor increased nitric oxide concentration in the alveolar level. None of the patients had a reduced FEV1/FVC or significant bronchodilator responses in IOS or spirometry. In conclusion, we found no evidence of inflammation or dysfunction in the small airways.
Follow-up studies of COVID-19 patients have found lung function impairment up to six months after initial infection, but small airway function has not previously been studied. Patients (n = 20) hospitalised for a severe SARS-CoV-2 infection underwent spirometry, impulse oscillometry, and multiple measurements of alveolar nitric oxide three to six months after acute infection. None of the patients had small airway obstruction, nor increased nitric oxide concentration in the alveolar level. None of the patients had a reduced FEV1/FVC or significant bronchodilator responses in IOS or spirometry. In conclusion, we found no evidence of inflammation or dysfunction in the small airways.
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