A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Assessment of a digital and an analog PET/CT system for accurate myocardial perfusion imaging with a flow phantom




TekijätSiekkinen Reetta, Kirjavainen Anna K, Koskensalo Kalle, Smith Nadia AS, Fenwick Andrew, Saunavaara Virva, Tolvanen Tuula, Iida Hidehiro, Saraste Antti, Teräs Mika, Teuho Jarmo

KustantajaSpringer

Julkaisuvuosi2022

JournalJournal of Nuclear Cardiology

Tietokannassa oleva lehden nimiJOURNAL OF NUCLEAR CARDIOLOGY

Lehden akronyymiJ NUCL CARDIOL

Vuosikerta29

Aloitussivu1964

Lopetussivu1972

Sivujen määrä9

ISSN1071-3581

eISSN1532-6551

DOIhttps://doi.org/10.1007/s12350-021-02631-9

Verkko-osoitehttps://link.springer.com/article/10.1007/s12350-021-02631-9

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/Publication/58940170


Tiivistelmä
In Myocardial Perfusion Imaging (MPI) with Positron Emission Tomography/Computed Tomography (PET/CT) systems, accurate quantification is essential. We assessed flow quantification accuracy over various injected activities using a flow phantom.Methods The study was performed on the digital 4-ring Discovery MI (DMI-20) and analog Discovery 690 (D690) PET/CT systems, using 325-1257 MBq of [O-15]H2O. PET performance and flow quantification accuracy were assessed in terms of count-rates, dead-time factors (DTF), scatter fractions (SF), time-activity curves (TACs), areas-under-the-curves (AUCs) and flow values.Results On DMI-20, prompts of 12.8 Mcps, DTF of 2.06 and SF of 46.1% were measured with 1257 MBq of activity. On the D690, prompts of 6.85 Mcps, DTF of 1.57 and SF of 32.5% were measured with 1230 MBq of activity. AUC values were linear over all activities. Mean wash-in flow error was - 9% for both systems whereas wash-out flow error was - 5% and - 6% for DMI-20 and D690. With the highest activity, wash-out flow error was - 12% and - 7% for the DMI-20 and D690.Conclusion DMI-20 and D690 preserved accurate flow quantification over all injected activities, with maximum error of - 12%. In the future, flow quantification accuracy over the activities and count-rates evaluated in this study should be assessed.

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