A1 Refereed original research article in a scientific journal
Assessment of a digital and an analog PET/CT system for accurate myocardial perfusion imaging with a flow phantom
Authors: Siekkinen Reetta, Kirjavainen Anna K, Koskensalo Kalle, Smith Nadia AS, Fenwick Andrew, Saunavaara Virva, Tolvanen Tuula, Iida Hidehiro, Saraste Antti, Teräs Mika, Teuho Jarmo
Publisher: Springer
Publication year: 2022
Journal: Journal of Nuclear Cardiology
Journal name in source: JOURNAL OF NUCLEAR CARDIOLOGY
Journal acronym: J NUCL CARDIOL
Volume: 29
First page : 1964
Last page: 1972
Number of pages: 9
ISSN: 1071-3581
eISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-021-02631-9
Web address : https://link.springer.com/article/10.1007/s12350-021-02631-9
Self-archived copy’s web address: https://research.utu.fi/converis/portal/Publication/58940170
In Myocardial Perfusion Imaging (MPI) with Positron Emission Tomography/Computed Tomography (PET/CT) systems, accurate quantification is essential. We assessed flow quantification accuracy over various injected activities using a flow phantom.Methods The study was performed on the digital 4-ring Discovery MI (DMI-20) and analog Discovery 690 (D690) PET/CT systems, using 325-1257 MBq of [O-15]H2O. PET performance and flow quantification accuracy were assessed in terms of count-rates, dead-time factors (DTF), scatter fractions (SF), time-activity curves (TACs), areas-under-the-curves (AUCs) and flow values.Results On DMI-20, prompts of 12.8 Mcps, DTF of 2.06 and SF of 46.1% were measured with 1257 MBq of activity. On the D690, prompts of 6.85 Mcps, DTF of 1.57 and SF of 32.5% were measured with 1230 MBq of activity. AUC values were linear over all activities. Mean wash-in flow error was - 9% for both systems whereas wash-out flow error was - 5% and - 6% for DMI-20 and D690. With the highest activity, wash-out flow error was - 12% and - 7% for the DMI-20 and D690.Conclusion DMI-20 and D690 preserved accurate flow quantification over all injected activities, with maximum error of - 12%. In the future, flow quantification accuracy over the activities and count-rates evaluated in this study should be assessed.
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