A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
A Distinct Cytokine Profile and Stromal Vascular Fraction Metabolic Status without Significant Changes in the Lipid Composition Characterizes Lipedema
Tekijät: Wolf Stefan, Deuel Jeremy W, Hollmen Maija, Felmerer Gunther, Kim Bong-Sung, Vasella Mauro, Grünherz Lisanne, Giovanoli Pietro, Lindenblatt Nicole, Gousopoulos Epameinondas
Kustantaja: MDPI
Kustannuspaikka: Basel
Julkaisuvuosi: 2021
Journal: International Journal of Molecular Sciences
Tietokannassa oleva lehden nimi: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lehden akronyymi: INT J MOL SCI
Artikkelin numero: ARTN 3313
Vuosikerta: 22
Numero: 7
Sivujen määrä: 14
eISSN: 1422-0067
DOI: https://doi.org/10.3390/ijms22073313
Verkko-osoite: http://www.doi.org/10.3390/ijms22073313
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/57561241
Lipedema is an adipose tissue disorder characterized by the disproportionate increase of subcutaneous fat tissue in the lower and/or upper extremities. The underlying pathomechanism remains unclear and no molecular biomarkers to distinguish the disease exist, leading to a large number of undiagnosed and misdiagnosed patients. To unravel the distinct molecular characteristic of lipedema we performed lipidomic analysis of the adipose tissue and serum of lipedema versus anatomically- and body mass index (BMI)-matched control patients. Both tissue groups showed no significant changes regarding lipid composition. As hyperplastic adipose tissue represents low-grade inflammation, the potential systemic effects on circulating cytokines were evaluated in lipedema and control patients using the Multiplex immunoassay system. Interestingly, increased systemic levels of interleukin 11 (p = 0.03), interleukin 28A (p = 0.04) and interleukin 29 (p = 0.04) were observed. As cytokines can influence metabolic activity, the metabolic phenotype of the stromal vascular fraction was examined, revealing significantly increased mitochondrial respiration in lipedema. In conclusion, despite sharing a comparable lipid profile with healthy adipose tissue, lipedema is characterized by a distinct systemic cytokine profile and metabolic activity of the stromal vascular fraction.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
