A1 Refereed original research article in a scientific journal
A Distinct Cytokine Profile and Stromal Vascular Fraction Metabolic Status without Significant Changes in the Lipid Composition Characterizes Lipedema
Authors: Wolf Stefan, Deuel Jeremy W, Hollmen Maija, Felmerer Gunther, Kim Bong-Sung, Vasella Mauro, Grünherz Lisanne, Giovanoli Pietro, Lindenblatt Nicole, Gousopoulos Epameinondas
Publisher: MDPI
Publishing place: Basel
Publication year: 2021
Journal: International Journal of Molecular Sciences
Journal name in source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Journal acronym: INT J MOL SCI
Article number: ARTN 3313
Volume: 22
Issue: 7
Number of pages: 14
eISSN: 1422-0067
DOI: https://doi.org/10.3390/ijms22073313(external)
Web address : http://www.doi.org/10.3390/ijms22073313(external)
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/57561241(external)
Lipedema is an adipose tissue disorder characterized by the disproportionate increase of subcutaneous fat tissue in the lower and/or upper extremities. The underlying pathomechanism remains unclear and no molecular biomarkers to distinguish the disease exist, leading to a large number of undiagnosed and misdiagnosed patients. To unravel the distinct molecular characteristic of lipedema we performed lipidomic analysis of the adipose tissue and serum of lipedema versus anatomically- and body mass index (BMI)-matched control patients. Both tissue groups showed no significant changes regarding lipid composition. As hyperplastic adipose tissue represents low-grade inflammation, the potential systemic effects on circulating cytokines were evaluated in lipedema and control patients using the Multiplex immunoassay system. Interestingly, increased systemic levels of interleukin 11 (p = 0.03), interleukin 28A (p = 0.04) and interleukin 29 (p = 0.04) were observed. As cytokines can influence metabolic activity, the metabolic phenotype of the stromal vascular fraction was examined, revealing significantly increased mitochondrial respiration in lipedema. In conclusion, despite sharing a comparable lipid profile with healthy adipose tissue, lipedema is characterized by a distinct systemic cytokine profile and metabolic activity of the stromal vascular fraction.
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