A1 Refereed original research article in a scientific journal
Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study
Authors: Oikarinen Maarit, Puustinen Leena, Lehtonen Jussi, Hakola Leena, Simell Satu, Toppari Jorma, Ilonen Jorma, Veijola Riitta, Virtanen Suvi M, Knip Mikael, Hyöty Heikki
Publisher: FRONTIERS MEDIA SA
Publication year: 2021
Journal: Frontiers in Immunology
Journal name in source: FRONTIERS IN IMMUNOLOGY
Journal acronym: FRONT IMMUNOL
Article number: ARTN 604529
Volume: 11
Number of pages: 6
ISSN: 1664-3224
DOI: https://doi.org/10.3389/fimmu.2020.604529
Web address : https://doi.org/10.3389/fimmu.2020.604529
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/53642918
Enterovirus and adenovirus infections have been linked to the development of celiac disease. We evaluated this association in children who developed biopsy-proven celiac disease (N = 41) during prospective observation starting from birth, and in control children (N = 53) matched for the calendar time of birth, sex, and HLA-DQ genotype. Enterovirus and adenovirus infections were diagnosed by seroconversions in virus antibodies in longitudinally collected sera using EIA. Enterovirus infections were more frequent in case children before the appearance of celiac disease-associated tissue transglutaminase autoantibodies compared to the corresponding period in control children (OR 6.3, 95% CI 1.8-22.3; p = 0.005). No difference was observed in the frequency of adenovirus infections. The findings suggest that enterovirus infections may contribute to the process leading to celiac disease.
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