A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Depression and Nigral Neuron Density in Lewy Body Spectrum Diseases
Tekijät: Saari Laura, Heiskanen Lauri, Gardberg Maria, Kaasinen Valtteri
Kustantaja: WILEY
Julkaisuvuosi: 2021
Journal: Annals of Neurology
Tietokannassa oleva lehden nimi: ANNALS OF NEUROLOGY
Lehden akronyymi: ANN NEUROL
Vuosikerta: 89
Numero: 5
Aloitussivu: 1046
Lopetussivu: 1050
Sivujen määrä: 5
ISSN: 0364-5134
DOI: https://doi.org/10.1002/ana.26046
Verkko-osoite: https://doi.org/10.1002/ana.26046
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/53395803
Parkinson's disease and other Lewy body spectrum diseases (LBDs) are associated with a specific risk for clinical depression. In the present clinicopathological study with 73 patients with LBD, we observed that the substantia nigra pars compacta dopamine neuron density was markedly lower in patients who had comorbid depression antemortem than in nondepressed patients (1.52 vs 2.32 n/mm(2), p = 0.004). There were no differences in cognition, motor disease severity, antiparkinsonian medications, or disease duration between groups. The results implicate the substantia nigra as an important psychomotor modulatory area of mood in patients with Lewy body disorders. ANN NEUROL 2021
Ladattava julkaisu This is an electronic reprint of the original article. |  |
