A1 Refereed original research article in a scientific journal
Depression and Nigral Neuron Density in Lewy Body Spectrum Diseases
Authors: Saari Laura, Heiskanen Lauri, Gardberg Maria, Kaasinen Valtteri
Publisher: WILEY
Publication year: 2021
Journal: Annals of Neurology
Journal name in source: ANNALS OF NEUROLOGY
Journal acronym: ANN NEUROL
Volume: 89
Issue: 5
First page : 1046
Last page: 1050
Number of pages: 5
ISSN: 0364-5134
DOI: https://doi.org/10.1002/ana.26046
Web address : https://doi.org/10.1002/ana.26046
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/53395803
Parkinson's disease and other Lewy body spectrum diseases (LBDs) are associated with a specific risk for clinical depression. In the present clinicopathological study with 73 patients with LBD, we observed that the substantia nigra pars compacta dopamine neuron density was markedly lower in patients who had comorbid depression antemortem than in nondepressed patients (1.52 vs 2.32 n/mm(2), p = 0.004). There were no differences in cognition, motor disease severity, antiparkinsonian medications, or disease duration between groups. The results implicate the substantia nigra as an important psychomotor modulatory area of mood in patients with Lewy body disorders. ANN NEUROL 2021
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