Adaptation of bacteria to glyphosate: a microevolutionary perspective of the enzyme 5-enolpyruvylshikimate-3-phosphate synthase

: Rainio Miia J, Ruuskanen Suvi, Helander Marjo, Saikkonen Kari, Saloniemi Irma, Puigbò Pere

Publisher: WILEY

: 2021

: Environmental Microbiology Reports

: ENVIRONMENTAL MICROBIOLOGY REPORTS

: ENV MICROBIOL REP

: 8

: 1758-2229

DOI: https://doi.org/10.1111/1758-2229.12931

: https://research.utu.fi/converis/portal/detail/Publication/53327474

Glyphosate is the leading herbicide worldwide, but it also affects prokaryotes because it targets the central enzyme (5-enolpyruvylshikimate-3-phosphate, EPSP) of the shikimate pathway in the synthesis of the three essential aromatic amino acids in bacteria, fungi and plants. Our results reveal that bacteria may easily become resistant to glyphosate through changes in the 5-enolpyruvylshikimate-3-phosphate synthase active site. This indicates the importance of examining how glyphosate affects microbe-mediated ecosystem functions and human microbiomes.

1758-2229.12931.pdf