A2 Refereed review article in a scientific journal
Evolving Concepts in Salivary Duct Carcinoma: A Narrative Review; 
Authors: Masalunga, Marvin C.; Bradley, Patrick J.; van Herpen, Carla; Nagao, Toshitaka; Stenman, Göran; Vander Poorten, Vincent; Hellquist, Henrik; Di Palma, Silvana; Bradová, Martina; Leivo, Ilmo; Ferlito, Alfio; Skálová, Alena
Publisher: Springer Nature
Publication year: 2026
Journal: Oncology and therapy
Volume: 14
Issue: 2
First page : 575
Last page: 595
ISSN: 2366-1070
eISSN: 2366-1089
DOI: https://doi.org/10.1007/s40487-026-00447-6
Publication's open availability at the time of reporting: Open Access
Publication channel's open availability : Open Access publication channel
Web address : https://link.springer.com/article/10.1007/s40487-026-00447-6
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/526738807
Self-archived copy's licence: CC BY NC
Self-archived copy's version: Publisher`s PDF
Salivary duct carcinoma (SDC) is an aggressive neoplasm that typically involves the major salivary glands. This rapidly growing tumor is known to recur and metastasize to the neck nodes and to distant sites. Given its poor prognosis, researchers have focused on identifying factors and driver genomic alterations that may account for its behavior, ultimately yielding potential therapeutic targets. This review summarizes the growing body of knowledge on SDC since the publication of the latest WHO Classification of Tumors of the Head and Neck. Updates on emerging subtypes, immunohistochemical profiles, molecular alterations, and potential therapeutic targets are succinctly presented. Findings from studies on tumor immune microenvironment (TIME), which may have implications for the treatment and prognosis of SDC, are also discussed in this narrative review.
Keywords:
Genetic alterations, HER2 expression, Molecular landscape, Salivary duct carcinoma, tumor immune microenvironment
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Funding information in the publication:
This study was supported by a study grant, the Cooperatio Program—research area SURG from Charles University, Czech Republic (MB, AS), the project National Institute for Cancer Research—NICR (Programme EXCELES, ID Project No. LX22NPO5102)—funded by the European Union—Next Generation EU (AS, MB), and the Finnish Cancer Society, Finska Lakaresallskapet, the Turku University Hospital Fund, and the Maritza and Reino Salonen Foundation, Finland (IL). No funding was received for the publication of this article.
