A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä

Evolving Concepts in Salivary Duct Carcinoma: A Narrative Review;



Tekijät: Masalunga, Marvin C.; Bradley, Patrick J.; van Herpen, Carla; Nagao, Toshitaka; Stenman, Göran; Vander Poorten, Vincent; Hellquist, Henrik; Di Palma, Silvana; Bradová, Martina; Leivo, Ilmo; Ferlito, Alfio; Skálová, Alena

Kustantaja: Springer Nature

Julkaisuvuosi: 2026

Lehti: Oncology and therapy

Vuosikerta: 14

Numero: 2

Aloitussivu: 575

Lopetussivu: 595

ISSN: 2366-1070

eISSN: 2366-1089

DOI: https://doi.org/10.1007/s40487-026-00447-6

Julkaisun avoimuus kirjaamishetkellä: Avoimesti saatavilla

Julkaisukanavan avoimuus : Kokonaan avoin julkaisukanava

Verkko-osoite: https://link.springer.com/article/10.1007/s40487-026-00447-6

Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/526738807

Rinnakkaistallenteen lisenssi: CC BY NC

Rinnakkaistallennetun julkaisun versio: Kustantajan versio


Tiivistelmä

Salivary duct carcinoma (SDC) is an aggressive neoplasm that typically involves the major salivary glands. This rapidly growing tumor is known to recur and metastasize to the neck nodes and to distant sites. Given its poor prognosis, researchers have focused on identifying factors and driver genomic alterations that may account for its behavior, ultimately yielding potential therapeutic targets. This review summarizes the growing body of knowledge on SDC since the publication of the latest WHO Classification of Tumors of the Head and Neck. Updates on emerging subtypes, immunohistochemical profiles, molecular alterations, and potential therapeutic targets are succinctly presented. Findings from studies on tumor immune microenvironment (TIME), which may have implications for the treatment and prognosis of SDC, are also discussed in this narrative review.



Avainsanat:
Genetic alterations, HER2 expression, Molecular landscape, Salivary duct carcinoma, tumor immune microenvironment

Ladattava julkaisu

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.

Julkaisussa olevat rahoitustiedot: 
This study was supported by a study grant, the Cooperatio Program—research area SURG from Charles University, Czech Republic (MB, AS), the project National Institute for Cancer Research—NICR (Programme EXCELES, ID Project No. LX22NPO5102)—funded by the European Union—Next Generation EU (AS, MB), and the Finnish Cancer Society, Finska Lakaresallskapet, the Turku University Hospital Fund, and the Maritza and Reino Salonen Foundation, Finland (IL). No funding was received for the publication of this article.


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