A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Low Mannose Binding Lectin, but Not L-Ficolin, Is Associated With Spontaneous Clearance of Hepatitis C Virus After Infection
Tekijät: Zhang Jing, Chen Ning, Chen Zhiyun, Liu Yali, Zheng Kai, Qiu Yundong, Zhang Nan, Zhu Junping, Yu Haibin, He Qiushui
Kustantaja: FRONTIERS MEDIA SA
Julkaisuvuosi: 2020
Journal: Frontiers in Immunology
Tietokannassa oleva lehden nimi: FRONTIERS IN IMMUNOLOGY
Lehden akronyymi: FRONT IMMUNOL
Artikkelin numero: ARTN 587669
Vuosikerta: 11
Sivujen määrä: 7
ISSN: 1664-3224
eISSN: 1664-3224
DOI: https://doi.org/10.3389/fimmu.2020.587669
Verkko-osoite: https://www.frontiersin.org/articles/10.3389/fimmu.2020.587669/full
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/51291351
Some individuals can spontaneously clear the hepatitis C virus (HCV) after infection, whereas others develop a chronic infection. The exact mechanism of this phenomenon is unknown. We aimed to evaluate the association of plasma levels of MBL, L-ficolin, and cytokines with outcome of HCV infections in two groups of patients who cleared HCV spontaneously (CHS), and who developed chronic HCV infections (CHC). Altogether, 86 patients and 183 healthy controls were included. Of 86 patients, 36 had CHS and 50 had CHC. Concentrations of plasma MBL and L-ficolin were measured in patients and controls. Twenty plasma cytokines and adhesion molecules, including GM-CSF, ICAM-1, IFN-gamma, IFN-alpha, IL-1 alpha, IL-1 beta, IL-10, IL-12p70, IL-13, IL-17A, IL-4, IL-8, IP-10, MCP-1, IL-6, MIP-1 alpha, MIP-1 beta, sE-Selectin, sP-Selectin, and TNF-alpha, were determined in all patients and randomly selected 45 controls. The level of MBL was significantly lower in subjects with CHS than in healthy controls (median: 293.10 vs. 482.64 ng/ml, p = 0.008), whereas the level of MBL was significantly higher in patients with CHC than in controls (median: 681.32 vs. 482.64 ng/ml, p = 0.001). No such differences in plasma L-ficolin were observed. Plasma levels of all cytokines and adhesion molecules, except ICAM-1, were significantly higher in patients than in controls. Moreover, patients with CHC had significantly higher levels of IFN-gamma, IFN-alpha, IL-1 alpha, IL-10, IL-13, IL-4, IL-6, and TNF-alpha than those with CHS. These findings implicate that lower levels of plasma MBL, together with lower levels of above mentioned cytokines may play a part in virus clearance of HCV infection.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
