A1 Refereed original research article in a scientific journal
Low Mannose Binding Lectin, but Not L-Ficolin, Is Associated With Spontaneous Clearance of Hepatitis C Virus After Infection
Authors: Zhang Jing, Chen Ning, Chen Zhiyun, Liu Yali, Zheng Kai, Qiu Yundong, Zhang Nan, Zhu Junping, Yu Haibin, He Qiushui
Publisher: FRONTIERS MEDIA SA
Publication year: 2020
Journal: Frontiers in Immunology
Journal name in source: FRONTIERS IN IMMUNOLOGY
Journal acronym: FRONT IMMUNOL
Article number: ARTN 587669
Volume: 11
Number of pages: 7
ISSN: 1664-3224
eISSN: 1664-3224
DOI: https://doi.org/10.3389/fimmu.2020.587669
Web address : https://www.frontiersin.org/articles/10.3389/fimmu.2020.587669/full
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/51291351
Some individuals can spontaneously clear the hepatitis C virus (HCV) after infection, whereas others develop a chronic infection. The exact mechanism of this phenomenon is unknown. We aimed to evaluate the association of plasma levels of MBL, L-ficolin, and cytokines with outcome of HCV infections in two groups of patients who cleared HCV spontaneously (CHS), and who developed chronic HCV infections (CHC). Altogether, 86 patients and 183 healthy controls were included. Of 86 patients, 36 had CHS and 50 had CHC. Concentrations of plasma MBL and L-ficolin were measured in patients and controls. Twenty plasma cytokines and adhesion molecules, including GM-CSF, ICAM-1, IFN-gamma, IFN-alpha, IL-1 alpha, IL-1 beta, IL-10, IL-12p70, IL-13, IL-17A, IL-4, IL-8, IP-10, MCP-1, IL-6, MIP-1 alpha, MIP-1 beta, sE-Selectin, sP-Selectin, and TNF-alpha, were determined in all patients and randomly selected 45 controls. The level of MBL was significantly lower in subjects with CHS than in healthy controls (median: 293.10 vs. 482.64 ng/ml, p = 0.008), whereas the level of MBL was significantly higher in patients with CHC than in controls (median: 681.32 vs. 482.64 ng/ml, p = 0.001). No such differences in plasma L-ficolin were observed. Plasma levels of all cytokines and adhesion molecules, except ICAM-1, were significantly higher in patients than in controls. Moreover, patients with CHC had significantly higher levels of IFN-gamma, IFN-alpha, IL-1 alpha, IL-10, IL-13, IL-4, IL-6, and TNF-alpha than those with CHS. These findings implicate that lower levels of plasma MBL, together with lower levels of above mentioned cytokines may play a part in virus clearance of HCV infection.
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