A2 Refereed review article in a scientific journal
The role of Interleukin-32 in autoimmunity
Authors: Albuquerque Rafael, Komsi Elina, Starskaia Inna, Ullah Ubaid, Lahesmaa Riitta
Publisher: WILEY
Publication year: 2021
Journal: Scandinavian Journal of Immunology
Journal name in source: SCANDINAVIAN JOURNAL OF IMMUNOLOGY
Journal acronym: SCAND J IMMUNOL
Article number: e13012
Volume: 93
Issue: 2
First page : e13012
Number of pages: 9
ISSN: 0300-9475
eISSN: 1365-3083
DOI: https://doi.org/10.1111/sji.13012(external)
Web address : https://onlinelibrary.wiley.com/doi/10.1111/sji.13012(external)
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/51228400(external)
Interleukin-32 (IL-32) is a pro-inflammatory cytokine that induces other cytokines involved in inflammation, including tumour necrosis factor (TNF)-alpha, IL-6 and IL-1 beta. Recent evidence suggests that IL-32 has a crucial role in host defence against pathogens, as well as in the pathogenesis of chronic inflammation. Abnormal IL-32 expression has been linked to several autoimmune diseases, such as rheumatoid arthritis and inflammatory bowel diseases, and a recent study suggested the importance of IL-32 in the pathogenesis of type 1 diabetes. However, despite accumulating evidence, many molecular characteristics of this cytokine, including the secretory route and the receptor for IL-32, remain largely unknown. In addition, the IL-32 gene is found in higher mammals but not in rodents. In this review, we outline the current knowledge of IL-32 biological functions, properties, and its role in autoimmune diseases. We particularly highlight the role of IL-32 in rheumatoid arthritis and type 1 diabetes.
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