Refereed review article in scientific journal (A2)

The role of Interleukin-32 in autoimmunity

List of Authors: Albuquerque Rafael, Komsi Elina, Starskaia Inna, Ullah Ubaid, Lahesmaa Riitta

Publisher: WILEY

Publication year: 2021

Journal: Scandinavian Journal of Immunology


Journal acronym: SCAND J IMMUNOL

Volume number: 93

Issue number: 2

Number of pages: 9

ISSN: 0300-9475

eISSN: 1365-3083



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Interleukin-32 (IL-32) is a pro-inflammatory cytokine that induces other cytokines involved in inflammation, including tumour necrosis factor (TNF)-alpha, IL-6 and IL-1 beta. Recent evidence suggests that IL-32 has a crucial role in host defence against pathogens, as well as in the pathogenesis of chronic inflammation. Abnormal IL-32 expression has been linked to several autoimmune diseases, such as rheumatoid arthritis and inflammatory bowel diseases, and a recent study suggested the importance of IL-32 in the pathogenesis of type 1 diabetes. However, despite accumulating evidence, many molecular characteristics of this cytokine, including the secretory route and the receptor for IL-32, remain largely unknown. In addition, the IL-32 gene is found in higher mammals but not in rodents. In this review, we outline the current knowledge of IL-32 biological functions, properties, and its role in autoimmune diseases. We particularly highlight the role of IL-32 in rheumatoid arthritis and type 1 diabetes.

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Last updated on 2022-07-04 at 18:16