A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Long-term intake of the illegal diet pill DNP reduces lifespan in a captive bird model




TekijätStier Antoine, Bize Pierre, Massemin Sylvie, Criscuolo François

KustantajaElsevier

Julkaisuvuosi2021

JournalComparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology

Tietokannassa oleva lehden nimiComparative biochemistry and physiology. Toxicology & pharmacology : CBP

Lehden akronyymiComp Biochem Physiol C Toxicol Pharmacol

Artikkelin numero108944

Vuosikerta242

ISSN1532-0456

eISSN1878-1659

DOIhttps://doi.org/10.1016/j.cbpc.2020.108944

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/Publication/51163246


Tiivistelmä
2,4-Dinitrophenol (DNP), a molecule uncoupling mitochondrial oxidative phosphorylation from oxygen consumption, is illegally used by humans as a diet pill, but is nonetheless investigated as a potential human medicine against ‘metabesity’. Due to its proven acute toxicity and the scarceness of long-term studies on DNP administration in vertebrates, we determined the impact of a long-term DNP treatment (~4 mg.kg−1.day−1, i.e. within the range taken illegally by humans) on body mass, metabolism, ageing and lifespan in a captive bird model, the zebra finch. The chronic absorption of DNP over life (>4 years) led to a mild increase in energy expenditure (ca. +11% compared to control group), without significantly altering the normal slight increase in body mass with age. DNP did not significantly influence the alteration of physical performance, the rise in oxidative damage, or the progressive shortening of telomeres with age. However, DNP-treated individuals had a significantly shorter lifespan (ca. -21% in median lifespan compared to control group), thereby raising potential concerns about DNP use as a diet pill or medicine.

Ladattava julkaisu

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.





Last updated on 2024-26-11 at 22:23