A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Long-term intake of the illegal diet pill DNP reduces lifespan in a captive bird model
Tekijät: Stier Antoine, Bize Pierre, Massemin Sylvie, Criscuolo François
Kustantaja: Elsevier
Julkaisuvuosi: 2021
Journal: Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology
Tietokannassa oleva lehden nimi: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
Lehden akronyymi: Comp Biochem Physiol C Toxicol Pharmacol
Artikkelin numero: 108944
Vuosikerta: 242
ISSN: 1532-0456
eISSN: 1878-1659
DOI: https://doi.org/10.1016/j.cbpc.2020.108944
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/Publication/51163246
2,4-Dinitrophenol (DNP), a molecule uncoupling mitochondrial oxidative phosphorylation from oxygen consumption, is illegally used by humans as a diet pill, but is nonetheless investigated as a potential human medicine against ‘metabesity’. Due to its proven acute toxicity and the scarceness of long-term studies on DNP administration in vertebrates, we determined the impact of a long-term DNP treatment (~4 mg.kg−1.day−1, i.e. within the range taken illegally by humans) on body mass, metabolism, ageing and lifespan in a captive bird model, the zebra finch. The chronic absorption of DNP over life (>4 years) led to a mild increase in energy expenditure (ca. +11% compared to control group), without significantly altering the normal slight increase in body mass with age. DNP did not significantly influence the alteration of physical performance, the rise in oxidative damage, or the progressive shortening of telomeres with age. However, DNP-treated individuals had a significantly shorter lifespan (ca. -21% in median lifespan compared to control group), thereby raising potential concerns about DNP use as a diet pill or medicine.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
