A1 Refereed original research article in a scientific journal
Indoor-related microbe damage induces complement system activation in building users
Authors: Atosuo Janne, Karhuvaara Outi, Suominen Eetu, Vilén Liisa, Nuutila Jari, Putus Tuula
Publication year: 2021
Journal: Innate Immunity
Journal name in source: Innate immunity
Journal acronym: Innate Immun
Volume: 27
Issue: 1
First page : 15
Last page: 22
Number of pages: 8
ISSN: 1753-4259
eISSN: 1753-4267
DOI: https://doi.org/10.1177/1753425920966641
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/51100543
In this comparative study, serum complement system antimicrobial activity was measured from 159 serum samples, taken from individuals from microbe-damaged (70 samples) and from reference buildings (89 samples). Antimicrobial activity was assessed using a probe-based bacterial Escherichia coli-lux bioluminescence system and comparison was made at a group level between the experimental and reference group. The complement activity was higher in users of microbe-damaged buildings compared with the reference group and the significant (P < 0.001) increase in activity was found in the classical reaction pathway. This study strengthens our notion that exposure to indoor-related microbe damage increases the risk for systemic subclinical inflammation and creates a health risk for building users.
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