A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Indoor-related microbe damage induces complement system activation in building users
Tekijät: Atosuo Janne, Karhuvaara Outi, Suominen Eetu, Vilén Liisa, Nuutila Jari, Putus Tuula
Julkaisuvuosi: 2021
Journal: Innate Immunity
Tietokannassa oleva lehden nimi: Innate immunity
Lehden akronyymi: Innate Immun
Vuosikerta: 27
Numero: 1
Aloitussivu: 15
Lopetussivu: 22
Sivujen määrä: 8
ISSN: 1753-4259
eISSN: 1753-4267
DOI: https://doi.org/10.1177/1753425920966641
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/51100543
In this comparative study, serum complement system antimicrobial activity was measured from 159 serum samples, taken from individuals from microbe-damaged (70 samples) and from reference buildings (89 samples). Antimicrobial activity was assessed using a probe-based bacterial Escherichia coli-lux bioluminescence system and comparison was made at a group level between the experimental and reference group. The complement activity was higher in users of microbe-damaged buildings compared with the reference group and the significant (P < 0.001) increase in activity was found in the classical reaction pathway. This study strengthens our notion that exposure to indoor-related microbe damage increases the risk for systemic subclinical inflammation and creates a health risk for building users.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
