A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Exploring the intersection of atherosclerosis and Alzheimer’s disease: the role of inflammation and complement activation
Tekijät: Vataja, Emilia; Ratti, Giorgio; Safa, Adrian; Pagano, Marta; Ferrante, Luigia; Meri, Seppo; Haapasalo, Karita
Kustantaja: Springer Science and Business Media LLC
Julkaisuvuosi: 2025
Lehti: Inflammation Research
Artikkelin numero: 102
Vuosikerta: 74
ISSN: 1023-3830
eISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-025-02069-6
Julkaisun avoimuus kirjaamishetkellä: Avoimesti saatavilla
Julkaisukanavan avoimuus : Osittain avoin julkaisukanava
Verkko-osoite: https://doi.org/10.1007/s00011-025-02069-6
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/506581361
Rinnakkaistallenteen lisenssi: CC BY
Rinnakkaistallennetun julkaisun versio: Kustantajan versio
Background: Atherosclerosis (AS) and Alzheimer's disease (AD) are both multifactorial in nature and share many risk factors. Vascular dementia and AD may occur together, and a substantial proportion of AD cases also have signs of cardiovascular disease, a relationship well-established by cohort studies. The risk factors could contribute to persistent smoldering inflammation, including activation of complement at sites of endothelial injury and/or by accumulation of molecular aggregates.
Methods: To examine the possible bridging points between AD and AS, we constructed a comprehensive narrative review.
Results: A connecting point between AD and AS is inflammation. Contrary to prior assumptions, a significant linkage exists between systemic inflammation and neuroinflammation. Activities of complement, a key effector of innate immunity, are of special interest in the pathogenesis of both diseases.
Conclusion: AS and AD share a partially overlapping array of pathophysiological mechanisms.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
