A2 Refereed review article in a scientific journal
Exploring the intersection of atherosclerosis and Alzheimer’s disease: the role of inflammation and complement activation
Authors: Vataja, Emilia; Ratti, Giorgio; Safa, Adrian; Pagano, Marta; Ferrante, Luigia; Meri, Seppo; Haapasalo, Karita
Publisher: Springer Science and Business Media LLC
Publication year: 2025
Journal: Inflammation Research
Article number: 102
Volume: 74
ISSN: 1023-3830
eISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-025-02069-6
Publication's open availability at the time of reporting: Open Access
Publication channel's open availability : Partially Open Access publication channel
Web address : https://doi.org/10.1007/s00011-025-02069-6
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/506581361
Self-archived copy's licence: CC BY
Self-archived copy's version: Publisher`s PDF
Background: Atherosclerosis (AS) and Alzheimer's disease (AD) are both multifactorial in nature and share many risk factors. Vascular dementia and AD may occur together, and a substantial proportion of AD cases also have signs of cardiovascular disease, a relationship well-established by cohort studies. The risk factors could contribute to persistent smoldering inflammation, including activation of complement at sites of endothelial injury and/or by accumulation of molecular aggregates.
Methods: To examine the possible bridging points between AD and AS, we constructed a comprehensive narrative review.
Results: A connecting point between AD and AS is inflammation. Contrary to prior assumptions, a significant linkage exists between systemic inflammation and neuroinflammation. Activities of complement, a key effector of innate immunity, are of special interest in the pathogenesis of both diseases.
Conclusion: AS and AD share a partially overlapping array of pathophysiological mechanisms.
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