A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Advanced Nanomaterials for Myocardial Ischemia-Reperfusion Injury: Bridging Precision Imaging to Targeted Therapy
Tekijät: Li, Jie; Shafiq, Muhammad; Yao, Minghua; Liu, Zehua; Tian, Ruizhi; Zheng, Fangqiao; Lu, Chan; Ma, Ming
Julkaisuvuosi: 2026
Lehti: Smart Materials in Medicine
Vuosikerta: 7
Aloitussivu: 13
Lopetussivu: 43
eISSN: 2590-1834
DOI: https://doi.org/10.1016/j.smaim.2025.12.003
Julkaisun avoimuus kirjaamishetkellä: Avoimesti saatavilla
Julkaisukanavan avoimuus : Kokonaan avoin julkaisukanava
Verkko-osoite: https://doi.org/10.1016/j.smaim.2025.12.003
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/506339709
Rinnakkaistallenteen lisenssi: CC BY
Rinnakkaistallennetun julkaisun versio: Kustantajan versio
This review presents functional nanomaterials as integrated theranostic platforms to overcome diagnostic and therapeutic bottlenecks in myocardial ischemia-reperfusion injury (MIRI).
It highlights advances in nano-biosensors for early biomarker detection and multimodal imaging for real-time, precise diagnosis.
Key therapeutic strategies are detailed, including nanozymes for antioxidative stress, biomimetic nanocarriers for targeted delivery, and gas-releasing agents for myocardial repair.
Major translational challenges are discussed, such as low cardiac targeting efficiency, long-term biosafety, and manufacturing scalability of biomimetic systems.
Future directions emphasize smart, stimuli-responsive nanoplatforms and AI-integrated closed-loop systems for personalized cardiovascular nanomedicine.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
Julkaisussa olevat rahoitustiedot:
This work was supported by the National Natural Science Foundation of China (Grant Nos. 52472290, 82171951), the Shanghai Outstanding Young Medical Talents Training Plan (Grant No. 2022YQ044), the Student Training Program for Innovation and Entrepreneurship of the Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences (UCAS), the Finnish Foundation for Cardiovascular Research, and the European Union’s Horizon Europe research and innovation program under the Marie Skłodowska-Curie grant agreement (Grant No. 10112661).
