A2 Refereed review article in a scientific journal
Advanced Nanomaterials for Myocardial Ischemia-Reperfusion Injury: Bridging Precision Imaging to Targeted Therapy
Authors: Li, Jie; Shafiq, Muhammad; Yao, Minghua; Liu, Zehua; Tian, Ruizhi; Zheng, Fangqiao; Lu, Chan; Ma, Ming
Publication year: 2026
Journal: Smart Materials in Medicine
Volume: 7
First page : 13
Last page: 43
eISSN: 2590-1834
DOI: https://doi.org/10.1016/j.smaim.2025.12.003
Publication's open availability at the time of reporting: Open Access
Publication channel's open availability : Open Access publication channel
Web address : https://doi.org/10.1016/j.smaim.2025.12.003
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/506339709
Self-archived copy's licence: CC BY
Self-archived copy's version: Publisher`s PDF
This review presents functional nanomaterials as integrated theranostic platforms to overcome diagnostic and therapeutic bottlenecks in myocardial ischemia-reperfusion injury (MIRI).
It highlights advances in nano-biosensors for early biomarker detection and multimodal imaging for real-time, precise diagnosis.
Key therapeutic strategies are detailed, including nanozymes for antioxidative stress, biomimetic nanocarriers for targeted delivery, and gas-releasing agents for myocardial repair.
Major translational challenges are discussed, such as low cardiac targeting efficiency, long-term biosafety, and manufacturing scalability of biomimetic systems.
Future directions emphasize smart, stimuli-responsive nanoplatforms and AI-integrated closed-loop systems for personalized cardiovascular nanomedicine.
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Funding information in the publication:
This work was supported by the National Natural Science Foundation of China (Grant Nos. 52472290, 82171951), the Shanghai Outstanding Young Medical Talents Training Plan (Grant No. 2022YQ044), the Student Training Program for Innovation and Entrepreneurship of the Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences (UCAS), the Finnish Foundation for Cardiovascular Research, and the European Union’s Horizon Europe research and innovation program under the Marie Skłodowska-Curie grant agreement (Grant No. 10112661).
