A2 Refereed review article in a scientific journal

Mortality and causes of death after surgery for chronic subdural hematoma: a post hoc study of the FINISH randomized trial




AuthorsTommiska, Pihla; Knuutinen, Oula; Lönnrot, Kimmo; Luoto, Teemu; Leinonen, Ville; Koivisto, Timo; Tetri, Sami; Posti, Jussi P.; Raj, Rahul; FINISH study group

PublisherSpringer Nature

Publication year2025

Journal: Acta Neurochirurgica

Article number310

Volume167

ISSN0001-6268

eISSN0942-0940

DOIhttps://doi.org/10.1007/s00701-025-06728-9

Publication's open availability at the time of reportingOpen Access

Publication channel's open availability Open Access publication channel

Web address https://doi.org/10.1007/s00701-025-06728-9

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/505792848


Abstract
Purpose

Chronic subdural hematoma (CSDH) is a common neurosurgical disease, especially prevalent among the elderly and is associated with reduced life expectancy. This study investigated mortality and causes of death after burr-hole drainage surgery for CSDH.

Methods

We included patients from the FINISH trial, a national, multicenter, randomized study conducted in Finland during 2020–2022. We obtained mortality data from Statistics Finland. For the classification of causes of death, we used the European shortlist of 86 causes, which is derived from the 10th revision of the International Classification of Diseases and Related Health Problems (ICD-10).

Results

Overall, the FINISH trial population included 589 patients (median age 78 years, 28% women). After a median follow-up of 16.4 months (IQR 9.7–23.1), 82 patients (14%) died. The median age at death was 85 years (IQR 81–89), and the median time from surgery to death was 6.5 months (IQR 2.4–15.3). The leading causes of death were circulatory diseases (34%), accidents (16%), and dementia (15%). A higher number of pre-existing comorbidities was significantly associated with increased mortality. In particular, dementia, cardiac arrhythmia, prior cerebrovascular events, and hypertension emerged as significant risk factors for death.

Conclusion

This study provides valuable insights into mortality rates and causes of death among patients undergoing CSDH surgery. The findings underscore the critical role of pre-existing comorbidities in influencing patient outcomes.


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Funding information in the publication
Open access funded by Helsinki University Library. The FINISH trial was supported by the State Fund for University Level Health Research (Helsinki University Hospital), Finska Läkaresällskapet, Svenska Kulturfonden and Medicinska Understödsföreningen Liv & Hälsa. The funders had no role in the study design, in the collection, analysis, or interpretation of data, in the writing of the report, or in the decision to submit the paper for publication.


Last updated on 10/12/2025 01:38:33 PM