Association of Peripheral Insulin Resistance and Other Markers of Type 2 Diabetes Mellitus with Brain Amyloid Deposition in Healthy Individuals at Risk of Dementia



: Timo Pekkala, Anette Hall, Francesca Mangialasche, Nina Kemppainen, Patrizia Mecocci, Tiia Ngandu, Juha O Rinne, Hilkka Soininen, Jaakko Tuomilehto, Miia Kivipelto, Alina Solomon

Publisher: IOS PRESS

: 2020

: Journal of Alzheimer's Disease

: JOURNAL OF ALZHEIMERS DISEASE

: J ALZHEIMERS DIS

: 76

: 4

: 1243

: 1248

: 6

: 1387-2877

: 1875-8908

DOI: https://doi.org/10.3233/JAD-200145(external)

: https://research.utu.fi/converis/portal/detail/Publication/50452402(external)


We explored the association of type 2 diabetes related blood markers with brain amyloid accumulation on PiB-PET scans in 41 participants from the FINGER PET sub-study. We built logistic regression models for brain amyloid status with12 plasma markers of glucose and lipid metabolism, controlled for diabetes and APOE epsilon 4 carrier status. Lower levels of insulin, insulin resistance index (HOMA-IR), C-peptide, and plasminogen activator (PAI-1) were associated with amyloid positive status, although the results were not significant after adjusting for multiple testing. None of the models found evidence for associations between amyloid status and fasting glucose or HbA1c.



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