Association of Peripheral Insulin Resistance and Other Markers of Type 2 Diabetes Mellitus with Brain Amyloid Deposition in Healthy Individuals at Risk of Dementia - UTU Research Portal

A1 Refereed original research article in a scientific journal

Association of Peripheral Insulin Resistance and Other Markers of Type 2 Diabetes Mellitus with Brain Amyloid Deposition in Healthy Individuals at Risk of Dementia

Authors: Timo Pekkala, Anette Hall, Francesca Mangialasche, Nina Kemppainen, Patrizia Mecocci, Tiia Ngandu, Juha O Rinne, Hilkka Soininen, Jaakko Tuomilehto, Miia Kivipelto, Alina Solomon

Publisher: IOS PRESS

Publication year: 2020

Journal: Journal of Alzheimer's Disease

Journal name in source: JOURNAL OF ALZHEIMERS DISEASE

Journal acronym: J ALZHEIMERS DIS

Volume: 76

Issue: 4

First page : 1243

Last page: 1248

Number of pages: 6

ISSN: 1387-2877

eISSN: 1875-8908

DOI: https://doi.org/10.3233/JAD-200145

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/50452402

Abstract

We explored the association of type 2 diabetes related blood markers with brain amyloid accumulation on PiB-PET scans in 41 participants from the FINGER PET sub-study. We built logistic regression models for brain amyloid status with12 plasma markers of glucose and lipid metabolism, controlled for diabetes and APOE epsilon 4 carrier status. Lower levels of insulin, insulin resistance index (HOMA-IR), C-peptide, and plasminogen activator (PAI-1) were associated with amyloid positive status, although the results were not significant after adjusting for multiple testing. None of the models found evidence for associations between amyloid status and fasting glucose or HbA1c.