Three‐Dimensional Presentation of Tongue Squamous Cell Carcinoma Histopathology and Magnetic Resonance Imaging—A Novel Image Fusion Method
: Koivuholma, Anne; Sistonen, Heli J.; Aro, Katri; Irace, Alexandria L.; Mäkitie, Antti; Hagström, Jaana; Atula, Timo
Publisher: John Wiley & Sons
: 2025
Head and Neck
: hed.70032
: 1043-3074
: 1097-0347
DOI: https://doi.org/10.1002/hed.70032
: https://doi.org/10.1002/hed.70032
: https://research.utu.fi/converis/portal/detail/Publication/500212469
Background
Three-dimensional (3D) modeling has been used in the management of bony head and neck tumors, but not in soft tissue tumors. Currently, histopathological findings of oral squamous cell carcinomas (OSCC) are presented as two-dimensional images. Previously, we developed a 3D image fusion method that presents tumor histopathology and MRI in 3D form. In this study, we sought to test our method in a series of OSCCs.
MethodsA 3D table scanner, 3D Slicer software, and 3D modeling software were used to produce 3D image fusions of nine OSCCs.
ResultsNine OSCCs are presented as digital, 3D image fusions, showing the resected specimen and the tumor within based on histopathology and MRI.
ConclusionsThe fused 3D model allows for a better visual understanding of tumor orientation within the resected specimen, provides a tool to compare tumor volume and dimensions between MRI images and histopathology slides, and facilitates multidisciplinary discussion.
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This work was supported by the Suomen Kulttuurirahasto, the Korvatautien Tutkimussäätiö, the Ida Montin Foundation, the Finnish Association of Otorhinolaryngology—Head and Neck Surgery, and the Finnish Cultural Foundation. Other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
