Three‐Dimensional Presentation of Tongue Squamous Cell Carcinoma Histopathology and Magnetic Resonance Imaging—A Novel Image Fusion Method - UTU Research Portal

A1 Refereed original research article in a scientific journal

Three‐Dimensional Presentation of Tongue Squamous Cell Carcinoma Histopathology and Magnetic Resonance Imaging—A Novel Image Fusion Method

Authors: Koivuholma, Anne; Sistonen, Heli J.; Aro, Katri; Irace, Alexandria L.; Mäkitie, Antti; Hagström, Jaana; Atula, Timo

Publisher: John Wiley & Sons

Publication year: 2025

Journal:: Head and Neck

Article number: hed.70032

ISSN: 1043-3074

eISSN: 1097-0347

DOI: https://doi.org/10.1002/hed.70032

Web address : https://doi.org/10.1002/hed.70032

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/500212469

Abstract

Background

Three-dimensional (3D) modeling has been used in the management of bony head and neck tumors, but not in soft tissue tumors. Currently, histopathological findings of oral squamous cell carcinomas (OSCC) are presented as two-dimensional images. Previously, we developed a 3D image fusion method that presents tumor histopathology and MRI in 3D form. In this study, we sought to test our method in a series of OSCCs.

Methods

A 3D table scanner, 3D Slicer software, and 3D modeling software were used to produce 3D image fusions of nine OSCCs.

Results

Nine OSCCs are presented as digital, 3D image fusions, showing the resected specimen and the tumor within based on histopathology and MRI.

Conclusions

The fused 3D model allows for a better visual understanding of tumor orientation within the resected specimen, provides a tool to compare tumor volume and dimensions between MRI images and histopathology slides, and facilitates multidisciplinary discussion.

Downloadable publication

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.

Head Neck - 2025 - Koivuholma - Three‐Dimensional Presentation of Tongue Squamous Cell Carcinoma Histopathology and.pdf

Funding information in the publication:
This work was supported by the Suomen Kulttuurirahasto, the Korvatautien Tutkimussäätiö, the Ida Montin Foundation, the Finnish Association of Otorhinolaryngology—Head and Neck Surgery, and the Finnish Cultural Foundation. Other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.