Cytoskeletal crosstalk in macrophages: Vimentin drives ECM remodeling in tumor invasion and tissue plasticity

: Eriksson, John E

Publisher: Cell Press

: 2025

: Developmental Cell

: 60

: 1534-5807

: 1878-1551

DOI: https://doi.org/10.1016/j.devcel.2025.05.015

: https://doi.org/10.1016/j.devcel.2025.05.015

In this issue of Developmental Cell, Huang et al. assess the role of vimentin intermediate filaments during extracellular matrix (ECM) degradation by macrophages. Vimentin stabilizes podosome clusters via CD11b in M2 macrophages, thereby reducing tumor collagen fiber and enhancing lung adenocarcinoma cancer invasion.