B1 Other refereed article (e.g., editorial, letter, comment) in a scientific journal

Cytoskeletal crosstalk in macrophages: Vimentin drives ECM remodeling in tumor invasion and tissue plasticity



Authors: Eriksson, John E

Publisher: Cell Press

Publication year: 2025

Journal: Developmental Cell

Journal name in source: Developmental Cell

Volume: 60

ISSN: 1534-5807

eISSN: 1878-1551

DOI: https://doi.org/10.1016/j.devcel.2025.05.015

Web address : https://doi.org/10.1016/j.devcel.2025.05.015


Abstract

In this issue of Developmental Cell, Huang et al. assess the role of vimentin intermediate filaments during extracellular matrix (ECM) degradation by macrophages. Vimentin stabilizes podosome clusters via CD11b in M2 macrophages, thereby reducing tumor collagen fiber and enhancing lung adenocarcinoma cancer invasion.



Last updated on 2025-19-09 at 14:54