Generation of two human induced pluripotent stem cell lines from peripheral blood mononuclear cells featuring normal or mutated STAB1 gene
: Sandelin, Sanne; Giannareas, Nikolaos; Kere, Juha; Seppänen, Mikko R. J.; Hollmen, Maija; Närvä, Elisa
Publisher: Elsevier
: AMSTERDAM
: 2025
: Stem Cell Research
: STEM CELL RESEARCH
: STEM CELL RES
: 103750
: 87
: 5
: 1873-5061
: 1876-7753
DOI: https://doi.org/10.1016/j.scr.2025.103750
: https://doi.org/10.1016/j.scr.2025.103750
: https://research.utu.fi/converis/portal/detail/Publication/498990284
Here, we report the establishment of a human induced pluripotent stem cell (hiPSC) line TUR-STAB1-B1 derived from peripheral blood mononuclear cells of a patient carrying heterozygous mutations 52,509,890 C>A 790L>I and 52,520,515 G>A 1872R>H on STAB1 gene in addition to a normal control cell line TUR-B1. The pluripotency, identity, quality, safety, and sequence of the mutation sites of the cell lines were confirmed. The generated patient-specific cell line will facilitate detailed studies of the STAB1 in various differentiated cell types.
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This work was supported by funding from ImmuDocs (Finnish National Doctoral Education Pilot), BioCity Turku Funding, Finland; Finnish Red Cross Blood Service, Finland; Sigrid Jusélius Foundation, Finland; Drug Research Doctoral Programme (DRDP), InFlames, The Foundation for Pediatric Research, Pediatric Research Center HUS Helsinki University Hospital Research Funds, Finland; and Emil Aaltonen Foundation, Finland.
