A1 Refereed original research article in a scientific journal

Humoral Immunity to Measles, Mumps, Rubella, Diphtheria, Tetanus and Pertussis After Cancer Treatment in Children



Authors: Sundell, Susanna; Laine, Miia; Järvelä, Liisa; Peltola, Ville; Vuorinen, Tytti; Lähteenmäki, Päivi; Schuez-Havupalo, Linnea

Publisher: Wiley

Publishing place: HOBOKEN

Publication year: 2025

Journal: Cancer reports

Journal name in source: Cancer Reports

Journal acronym: CANCER REP-US

Article number: e70155

Volume: 8

Issue: 5

Number of pages: 7

ISSN: 2573-8348

eISSN: 2573-8348

DOI: https://doi.org/10.1002/cnr2.70155

Web address : https://doi.org/10.1002/cnr2.70155

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/498504843


Abstract
Background

Treatment for pediatric malignancies has distinct effects on the immune system.

Aims

Our aim was to measure humoral immunity to measles, mumps and rubella (MMR), and diphtheria, tetanus and acellular pertussis (DTaP) vaccines after pediatric cancer treatment.

Method

We assessed IgG titers of 52 children against the vaccine antigens post-treatment.

Results

After completed primary vaccination series for MMR and DTaP before treatment, post-treatment there was a considerable proportion of patients with below-reference titers against pertussis, diphtheria and tetanus, but only few subjects showed below-reference titers against measles, mumps and rubella. Our findings may have implications when considering re-vaccination policies.


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Funding information in the publication: 
This work was supported by the Turku University Hospital Foundation.


Last updated on 2025-19-06 at 13:52