Review of strategies to improve adherence to lipid-lowering therapy in the primary prevention of cardiovascular disease

: Whitmore, Kristyn; Zhou, Zhen; Magnussen, Costan G.; Nelson, Mark R.; Carrington, Melinda J.

Publisher: OXFORD UNIV PRESS

: OXFORD

: 2025

: European Journal of Preventive Cardiology

: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY

: EUR J PREV CARDIOL

: 12

: 2047-4873

: 2047-4881

DOI: https://doi.org/10.1093/eurjpc/zwaf237

: https://doi.org/10.1093/eurjpc/zwaf237

Poor adherence to lipid-lowering therapy (LLT) is a major barrier in the prevention of cardiovascular disease (CVD) worldwide. The burden of CVD can be significantly reduced by LLT, particularly in populations with high cardiovascular (CV) risk. Despite established benefits from LLT, efforts to improve adherence have had varying degrees of success in the primary prevention. Adherence is a multifactorial process and requires tailored strategies to address an individual's specific needs. Despite numerous studies exploring strategies to improve medication adherence, empirical evidence indicates that adherence to LLT remains a persistent challenge. Strategies used to improve long-term LLT adherence in the primary prevention can be grouped into four themes: (i) individualized CV education; (ii) emotional engagement with CV prevention; (iii) mobile health prompts; and (iv) approaches to improving patient acceptability of LLT. This review will revisit the strategies used to improve LLT adherence in the primary prevention of CVD and evaluate their effectiveness in promoting long-term adherence. Future perspectives for enhancing LLT adherence will explore the application of behavioural economic principles to facilitate shared decision-making, the development of novel communication strategies, and implementation of targeted interventions.

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M.J.C. received an endowed fellowship in the Cardiology Centre of Excellence from Filippo and Maria Casella.