A2 Refereed review article in a scientific journal
Review of strategies to improve adherence to lipid-lowering therapy in the primary prevention of cardiovascular disease
Authors: Whitmore, Kristyn; Zhou, Zhen; Magnussen, Costan G.; Nelson, Mark R.; Carrington, Melinda J.
Publisher: OXFORD UNIV PRESS
Publishing place: OXFORD
Publication year: 2025
Journal: European Journal of Preventive Cardiology
Journal name in source: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
Journal acronym: EUR J PREV CARDIOL
Number of pages: 12
ISSN: 2047-4873
eISSN: 2047-4881
DOI: https://doi.org/10.1093/eurjpc/zwaf237
Web address : https://doi.org/10.1093/eurjpc/zwaf237
Poor adherence to lipid-lowering therapy (LLT) is a major barrier in the prevention of cardiovascular disease (CVD) worldwide. The burden of CVD can be significantly reduced by LLT, particularly in populations with high cardiovascular (CV) risk. Despite established benefits from LLT, efforts to improve adherence have had varying degrees of success in the primary prevention. Adherence is a multifactorial process and requires tailored strategies to address an individual's specific needs. Despite numerous studies exploring strategies to improve medication adherence, empirical evidence indicates that adherence to LLT remains a persistent challenge. Strategies used to improve long-term LLT adherence in the primary prevention can be grouped into four themes: (i) individualized CV education; (ii) emotional engagement with CV prevention; (iii) mobile health prompts; and (iv) approaches to improving patient acceptability of LLT. This review will revisit the strategies used to improve LLT adherence in the primary prevention of CVD and evaluate their effectiveness in promoting long-term adherence. Future perspectives for enhancing LLT adherence will explore the application of behavioural economic principles to facilitate shared decision-making, the development of novel communication strategies, and implementation of targeted interventions.
Funding information in the publication:
M.J.C. received an endowed fellowship in the Cardiology Centre of Excellence from Filippo and Maria Casella.
